ArticleNature communications2017
Percolation transition of cooperative mutational effects in colorectal tumorigenesis.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- A randomized trial of a wearable UV dosimeter for skin cancer prevention.Frontiers in medicine · 2024Article
- Critical transition and reversion of tumorigenesis.Experimental & molecular medicine · 2023Review
- Network-based machine learning approach to predict immunotherapy response in cancer patients.Nature communications · 2022Article
- Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View.Genes · 2022Review
- Prediction of Synergistic Antibiotic Combinations by Graph Learning.Frontiers in pharmacology · 2022Article
- Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities.Theranostics · 2022Article
- Identification of Warning Transition Points from Hepatitis B to Hepatocellular Carcinoma Based on Mutation Accumulation for the Early Diagnosis and Potential Drug Treatment of HBV-HCC.Oxidative medicine and cellular longevity · 2022Article
- Feedback analysis identifies a combination target for overcoming adaptive resistance to targeted cancer therapy.Oncogene · 2020Article
- Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis.Frontiers in bioengineering and biotechnology · 2020Article
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- Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.Medical sciences (Basel, Switzerland) · 2018Review
- Topological estimation of signal flow in complex signaling networks.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is caused by the accumulation of multiple genetic mutations, but their cooperative effects are poorly understood. Using a genome-wide analysis of all the somatic mutations in colorectal cancer patients in a large-scale molecular interaction network, here we find that a giant cluster of mutation-propagating modules in the network undergoes a percolation transition, a sudden critical transition from scattered small modules to a large connected cluster, during colorectal tumorigenesis. Such a large cluster ultimately results in a giant percolated cluster, which is accompanied by phenotypic changes corresponding to cancer hallmarks. Moreover, we find that the most commonly observed sequence of driver mutations in colorectal cancer has been optimized to maximize the giant percolated cluster. Our network-level percolation study shows that the cooperative effect rather than any single dominance of multiple somatic mutations is crucial in colorectal tumorigenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.