ArticleScientific reports2017
Changes in GABAergic markers accompany degradation of neuronal function in the primary visual cortex of senescent rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Deprivation of visual input alters specific subset of inhibitory neurons and affect thalamic afferent terminals in V1 ofFrontiers in cellular neuroscience · 2024Article
- Rapidly repeated visual stimulation induces long-term potentiation of VEPs and increased content of membrane AMPA and NMDA receptors in the V1 cortex of cats.Frontiers in neuroscience · 2024Article
- Age-related dysregulation of homeostatic control in neuronal microcircuits.Nature neuroscience · 2023Article
- Multistable perception elicits compensatory alpha activity in older adults.Frontiers in aging neuroscience · 2023Article
- Synchrony in auditory 40-Hz gamma oscillations increases in older age and correlates with hearing abilities and cortical GABA levels.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Dysregulation of excitatory neural firing replicates physiological and functional changes in aging visual cortex.PLoS computational biology · 2021Article
- Brain Network Segregation and Glucose Energy Utilization: Relevance for Age-Related Differences in Cognitive Function.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1.Protein & cell · 2020Article
- Age-related neural dedifferentiation and cognition.Current opinion in behavioral sciences · 2020Article
- Characterization of Feedback Neurons in the High-Level Visual Cortical Areas That Project Directly to the Primary Visual Cortex in the Cat.Frontiers in neuroanatomy · 2020Article
- Neural Dedifferentiation in the Aging Brain.Trends in cognitive sciences · 2019Review
- Axon initial segment plasticity accompanies enhanced excitation of visual cortical neurons in aged rats.Neuroreport · 2018Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have reported age-dependent degradation of neuronal function in the visual cortex and have attributed this functional decline to weakened intracortical inhibition, especially GABAergic inhibition. However, whether this type of functional decline is linked to compromised GABAergic inhibition has not been fully confirmed. Here, we compared the neuronal response properties and markers of GABAergic inhibition in the primary visual cortex (V1) of young adult and senescent rats. Compared with those of young adult rats, old rats' V1 neurons exhibited significantly increased visually evoked responses and spontaneous activity, a decreased signal-to-noise ratio and reduced response selectivity for the stimulus orientation and motion direction. Additionally, the ratio of GABA-positive neurons to total cortical neurons in old rats was significantly decreased compared with that in young rats. Expression of the key GABA-synthesizing enzyme GAD67 was significantly lower in old rats than in young rats, although GAD65 expression showed a marginal difference between the two age groups. Further, expression of an important GABA
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