ArticleScientific reports2017
Proof-of-concept Raman spectroscopy study aimed to differentiate thyroid follicular patterned lesions.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04040673 (Evaluation of the Role of Vibrational Spectroscopy in the Diagnosis of Premalignant and Malignant Disease of the Thyroid RAFTER), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Evaluation of the Role of Vibrational Spectroscopy in the Diagnosis of Premalignant and Malignant Disease of the Thyroid RAFTER (RAman For Thyroid cancER)
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Pathology diagnosis of intraoperative frozen thyroid lesions assisted by deep learning.BMC cancer · 2024Article
- Label-Free Surface-Enhanced Raman Spectroscopy with Machine Learning for the Diagnosis of Thyroid Cancer by Using Fine-Needle Aspiration Liquid Samples.Biosensors · 2024Article
- Intraoperative rapid assessment of the deep muscle surgical margin of tongue squamous cell carcinoma via Raman spectroscopy.Frontiers in bioengineering and biotechnology · 2024Article
- An eXplainable Artificial Intelligence analysis of Raman spectra for thyroid cancer diagnosis.Scientific reports · 2023Article
- Identification of Healthy Tissue from Malignant Tissue in Surgical Margin Using Raman Spectroscopy in Oral Cancer Surgeries.Biomedicines · 2023Article
- How molecular imaging will enable robotic precision surgery : The role of artificial intelligence, augmented reality, and navigation.European journal of nuclear medicine and molecular imaging · 2021Review
- Developing an Algorithm for Discriminating Oral Cancerous and Normal Tissues Using Raman Spectroscopy.Journal of personalized medicine · 2021Article
- Thyroid cancer diagnosis by Raman spectroscopy.Scientific reports · 2020Article
- Multi-Reader Multi-Case Study for Performance Evaluation of High-Risk Thyroid Ultrasound with Computer-Aided Detection.Cancers · 2020Article
- Hyperspectral Raman microscopy can accurately differentiate single cells of different human thyroid nodules.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inter-observer variability and cancer over-diagnosis are emerging clinical problems, especially for follicular patterned thyroid lesions. This challenge strongly calls for a new clinical tool to reliably identify neoplastic lesions and to improve the efficiency of differentiation between benign and malignant neoplasms, especially considering the increased diagnosis of small carcinomas and the growing number of thyroid nodules. In this study, we employed a Raman spectroscopy (RS) microscope to investigate frozen thyroid tissues from fourteen patients with thyroid nodules. To generate tissue classification models, a supervised statistical analysis of the Raman spectra was performed. The results obtained demonstrate an accuracy of 78% for RS based diagnosis to discriminate between normal parenchyma and follicular patterned thyroid nodules, and 89% accuracy - for very challenging follicular lesions (carcinoma versus adenoma). RS translation into intraoperative diagnosis of frozen sections and in preoperative analysis of biopsies can be very helpful to reduce unnecessary surgery in patients with indeterminate cytological reports.
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