ArticlePediatrics2017
Generalizability of Clinical Trial Results for Adolescent Major Depressive Disorder.
Article in Pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Calibrated meta-analysis to estimate the efficacy of mental health treatments in target populations: an application to paliperidone trials for treatment of schizophrenia.BMC medical research methodology · 2023Pooled it
- Ineligibility for and Refusal to Participate in Randomized Controlled Trials That Have Studied Impact on Suicide-Related Outcomes in the United States: A Meta-Analysis.The Journal of clinical psychiatry · 2022Pooled it
- The Generalizability of Randomized Controlled Trials of Self-Guided Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms: Systematic Review and Meta-Regression Analysis.Journal of medical Internet research · 2018Pooled it
- The Kids FACE FEARS Pragmatic Randomized Trial of Therapist-Led vs Guided Internet Cognitive Behavioral Therapy for Pediatric Anxiety: Rationale and Methods.JAACAP open · 2026Article
- Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts.World journal of psychiatry · 2026Article
- Understanding adolescent mental health symptom progression in school-based settings: The Substance Use and Risk Factors (SURF) longitudinal survey.School psychology (Washington, D.C.) · 2025Article
- Assessment of digital therapeutics in decentralized clinical trials: A scoping review.PLOS digital health · 2025Article
- Cytomegalovirus Infection Affects the Differentiation and Determines the Functionality of a Human Progenitor Neural Cell Line.Current microbiology · 2025Article
- Evidence for machine learning guided early prediction of acute outcomes in the treatment of depressed children and adolescents with antidepressants.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Turning data into better mental health: Past, present, and future.Frontiers in digital health · 2022Review
- Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2022Article
- Examination of exclusion criteria in total knee arthroplasty rehabilitation trials: influence on the application of evidence in day-to-day practice.Journal of evaluation in clinical practice · 2021Article
- Inclusion of Cannabis Users in Alcohol Research Samples: Screening In, Screening Out, and Implications.Alcohol and alcoholism (Oxford, Oxfordshire) · 2020Article
- Tracking and Predicting Depressive Symptoms of Adolescents Using Smartphone-Based Self-Reports, Parental Evaluations, and Passive Phone Sensor Data: Development and Usability Study.JMIR mental health · 2020Article
- Emerging Methodologies in Pediatric Palliative Care Research: Six Case Studies.Children (Basel, Switzerland) · 2018Review
- Amygdala functional connectivity in female patients with major depressive disorder with and without suicidal ideation.Annals of general psychiatry · 2018Article
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Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundAlthough there have been a number of clinical trials evaluating treatments for adolescents with major depressive disorder (MDD), the generalizability of those trials to samples of depressed adolescents who present for routine clinical care is unknown. Examining the generalizability of clinical trials of pharmacological and psychotherapy interventions for adolescent depression can help administrators and frontline practitioners determine the relevance of these studies for their patients and may also guide eligibility criteria for future clinical trials in this clinical population.
methodsData on nationally representative adolescents were derived from the National Comorbidity Survey: Adolescent Supplement. To assess the generalizability of adolescent clinical trials for MDD, we applied a standard set of eligibility criteria representative of clinical trials to all adolescents in the National Comorbidity Survey: Adolescent Supplement with a
resultsFrom the overall MDD sample, 61.9% would have been excluded from a typical pharmacological trial, whereas 42.2% would have been excluded from a psychotherapy trial. Among those who sought treatment (
conclusionsPharmacological and, to a lesser extent, psychotherapy clinical trials likely exclude most adolescents with MDD. Careful consideration should be given to balancing eligibility criteria and internal validity with applicability in routine clinical care while ensuring patient safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.