Evidence map›Paper›PMID 29097498›Full record

ArticleHaematologica2018

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major.

Carla Casu, Vania Lo Presti, Paraskevi Rea Oikonomidou, Luca Melchiori, Osheiza Abdulmalik, Pedro Ramos, Stefano Rivella

Abstract readLetter
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Advancing the care of β-thalassaemia patients with novel therapies.Blood transfusion = Trasfusione del sangue · 2022
    Review
  8. Review
  9. The Role of Iron in Benign and Malignant Hematopoiesis.Antioxidants & redox signaling · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carla CasuDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), PA, USA.
Vania Lo PrestiDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), PA, USA.
Paraskevi Rea OikonomidouDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), PA, USA.
Luca MelchioriAdaptimmune Therapeutics Ltd., Abingdon, UK.
Osheiza AbdulmalikDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), PA, USA.
Pedro RamosNovartis Pharma AG, Basel, Switzerland.
Stefano RivellaDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia (CHOP), PA, USA rivellas@email.chop.edu.

Funding

Regulatory Role of Transferrin in Erythropoiesis and Iron MetabolismR01DK095112 · NIDDK · SAINT LOUIS UNIVERSITY · PI Robert E Fleming, Yelena Ginzburg · 2012 to 2026
$5.4M
Hepcidin therapy for iron overload and hematologic disordersR01DK090554 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2021
$5.2M
NIDDK NIH HHS R01 DK090554NIDDK NIH HHS R01 DK095112
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Animalsbeta-ThalassemiaBlood TransfusionJanus Kinase 2MiceProtein Kinase InhibitorsSplenomegalyJak2 protein, mouseJanus Kinase 2Protein Kinase Inhibitors

Identifiers

PMID29097498
PMCPMC5792284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.