ArticleBioscience reports2018
Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion.
Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis.Clinical cardiology · 2019Pooled it
- A Randomized Trial on Resveratrol Supplement Affecting Lipid Profile and Other Metabolic Markers in Subjects with Dyslipidemia.Nutrients · 2023Trial
- Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026Review
- A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid.Neuroscience bulletin · 2025Review
- Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis.Journal of translational medicine · 2024Article
- Identification of Potential Biomarkers for Patients with DWI-Negative Ischemic Stroke.Journal of molecular neuroscience : MN · 2024Article
- Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review.Neurochemical research · 2023Review
- Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients.Renal failure · 2023Article
- Effects of a Macroporous Resin Extract ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- The relationship between serum uric acid levels and glomerular ischemic lesions in patients with Immunoglobin A nephropathy-a analytical cross-sectional study.BMC nephrology · 2022Article
- Potential ProbioticMicroorganisms · 2022Article
- Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults.Frontiers in aging neuroscience · 2022Article
- Detrimental effects of long-term elevated serum uric acid on cognitive function in rats.Scientific reports · 2021Article
- Article
- Inflammatory Response and Oxidative Stress as Mechanism of Reducing Hyperuricemia ofOxidative medicine and cellular longevity · 2021Article
- Oxidative Stress and Inflammation Are Associated with Coexistent Severe Multivessel Coronary Artery Stenosis and Right Carotid Artery Severe Stenosis in Elderly Patients.Oxidative medicine and cellular longevity · 2021Article
- Lipoxin A4 attenuates uric acid-activated, NADPH oxidase-dependent oxidative stress by interfering with translocation of p47phox in human umbilical vein endothelial cells.Experimental and therapeutic medicine · 2020Article
- Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension.Journal of geriatric cardiology : JGC · 2020Article
- miR-214 Protects Against Uric Acid-Induced Endothelial Cell Apoptosis.Frontiers in medicine · 2020Article
- Protective Effects of α-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia.Current medical science · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate the occurrence and development of carotid atherosclerosis (AS). Our study intended to explore the underlying mechanism. We enrolled 86 patients with CI, and divided them into four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative stress-related factors in serum were detected. The middle cerebral artery occlusion (MCAO) model was used to stimulate CI in rats, and different doses of UA were administrated. The levels of oxidative stress-related factors in serum were detected. Hematoxylin & eosin (H&E) staining was used to observe the morphological alterations, and the apoptotic cell death detection kit was used to detect apoptotic cells. Increased UA concentration and enhanced oxidative stress were found in AS patients. H&E staining results showed that UA treatment exacerbated morphological damage in rats with MCAO, promoted oxidative stress, and enhanced vascular endothelial cell apoptosis in rats with MCAO.
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