ArticleGenetics2018
The Evolution of Gene-Specific Transcriptional Noise Is Driven by Selection at the Pathway Level.
Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs in three ray-finned fishes.bioRxiv : the preprint server for biology · 2026Article
- Assessment of dispersion metrics for estimating single-cell transcriptional variability.PLoS computational biology · 2026Article
- Environmental perturbation increases gene expression variability and unmasks genetic regulation for transcriptional robustness.bioRxiv : the preprint server for biology · 2026Article
- Relationships between gene expression variability, expression levels, and Protein-Protein interactions in mouse and yeast.PloS one · 2026Article
- Article
- The Genomic Kaleidoscope: On the Hidden Dimensions of Within-Species Genomic Diversity.Genome biology and evolution · 2025Review
- The Role of Alternative Splicing in Marine-Freshwater Divergence in Threespine Stickleback.Genome biology and evolution · 2025Article
- Stress-Induced Constraint on Expression Noise of Essential Genes in E. coli.Journal of molecular evolution · 2024Article
- Molecular models of bidirectional promoter regulation.Current opinion in structural biology · 2024Review
- Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder.Schizophrenia (Heidelberg, Germany) · 2024Article
- Being noisy in a crowd: Differential selective pressure on gene expression noise in model gene regulatory networks.PLoS computational biology · 2023Article
- Stability in gene expression and body-plan development leads to evolutionary conservation.EvoDevo · 2023Article
- Transcriptional noise adjusted for expression levels reveals genes with high transcriptional noise that are highly expressed, functionally related, and co-regulated in yeast.Current genetics · 2022Article
- Comparative studies of genomic and epigenetic factors influencing transcriptional variation in two insect species.G3 (Bethesda, Md.) · 2022Article
- Rhythmicity is linked to expression cost at the protein level but to expression precision at the mRNA level.PLoS computational biology · 2022Article
- Potential contribution of intrinsic developmental stability toward body plan conservation.BMC biology · 2022Article
- Hematopoietic differentiation is characterized by a transient peak of entropy at a single-cell level.BMC biology · 2022Article
- A computational exploration of resilience and evolvability of protein-protein interaction networks.Communications biology · 2021Article
- Independent control of mean and noise by convolution of gene expression distributions.Nature communications · 2021Article
- Different Patterns of mRNA Nuclear Retention during Meiotic Prophase in Larch Microsporocytes.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biochemical reactions within individual cells result from the interactions of molecules, typically in small numbers. Consequently, the inherent stochasticity of binding and diffusion processes generates noise along the cascade that leads to the synthesis of a protein from its encoding gene. As a result, isogenic cell populations display phenotypic variability even in homogeneous environments. The extent and consequences of this stochastic gene expression have only recently been assessed on a genome-wide scale, owing, in particular, to the advent of single-cell transcriptomics. However, the evolutionary forces shaping this stochasticity have yet to be unraveled. Here, we take advantage of two recently published data sets for the single-cell transcriptome of the domestic mouse
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.