Evidence map›Paper›PMID 29097404›Full record

ArticleGenome research2017

Deep learning of the regulatory grammar of yeast 5' untranslated regions from 500,000 random sequences.

Josh T Cuperus, Benjamin Groves, Anna Kuchina, Alexander B Rosenberg, Nebojsa Jojic, Stanley Fields, Georg Seelig

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it, 230 citations in OpenAlex.

  1. Pooled it
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  7. A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  17. Biocontrol Effect ofMicroorganisms · 2025
    Article
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Josh T CuperusDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.ORCID 0000-0002-8019-7733
Benjamin GrovesDepartment of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA.
Anna KuchinaDepartment of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA.
Alexander B RosenbergDepartment of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA.
Nebojsa JojicMicrosoft Research, Seattle, Washington 98195, USA.
Stanley FieldsDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Georg SeeligDepartment of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA.
University of Washington · USHoward Hughes Medical Institute · USMicrosoft (United States) · US

Funding

TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
Howard Hughes Medical InstituteNIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

Our ability to predict protein expression from DNA sequence alone remains poor, reflecting our limited understanding of

Indexed as

Models, Genetic5' Untranslated RegionsAlternative SplicingComputer SimulationGene LibraryMachine LearningNeural Networks, ComputerRNA, FungalRNA, MessengerSaccharomyces cerevisiae5' Untranslated RegionsRNA, FungalRNA, Messenger

Identifiers

PMID29097404
PMCPMC5741052
OpenAlexW2951203227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.