Evidence map›Paper›PMID 29097381›Full record

ArticleBlood2018

Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study.

Ali T Taher, Zeynep Karakas, Elena Cassinerio, Noppadol Siritanaratkul, Antonis Kattamis, Aurelio Maggio, Stefano Rivella, Norbert Hollaender, Bruyère Mahuzier, Brian Gadbaw and 1 more

Abstract readLetterComment
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Thalassaemia.Nature reviews. Disease primers · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Advancing the care of β-thalassaemia patients with novel therapies.Blood transfusion = Trasfusione del sangue · 2022
    Review
  13. β-Thalassemia: evolving treatment options beyond transfusion and iron chelation.Hematology. American Society of Hematology. Education Program · 2021
    Review
  14. Article
  15. Review
  16. The Role of Iron in Benign and Malignant Hematopoiesis.Antioxidants & redox signaling · 2021
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ali T TaherDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.ORCID 0000-0001-8515-2238
Zeynep KarakasDepartment of Pediatric Hematology and Oncology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.
Elena CassinerioUniversità di Milano, Ca Granda Foundation Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.
Noppadol SiritanaratkulDepartment of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Antonis KattamisFirst Department of Pediatrics, University of Athens, Athens, Greece.
Aurelio MaggioCampus of Haematology Franco e Piera Cutino Azienda Ospedaliera Ospedali Riuniti Villa Sofia V. Cervello, Palermo, Italy.
Stefano RivellaDepartment of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Norbert HollaenderNovartis Pharma AG, Basel, Switzerland.
Bruyère MahuzierNovartis Pharma S.A.S., Rueil Malmaison, France.
Brian GadbawNovartis Pharmaceuticals Corporation, East Hanover, NJ; and.
Yesim AydinokEge University Hospital, Department of Pediatric Hematology and Oncology, Izmir, Turkey.

Funding

Regulatory Role of Transferrin in Erythropoiesis and Iron MetabolismR01DK095112 · NIDDK · SAINT LOUIS UNIVERSITY · PI Robert E Fleming, Yelena Ginzburg · 2012 to 2026
$5.4M
Hepcidin therapy for iron overload and hematologic disordersR01DK090554 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2021
$5.2M
NIDDK NIH HHS R01 DK090554NIDDK NIH HHS R01 DK095112
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

beta-ThalassemiaThalassemiaErythroid CellsErythropoiesisHumansNitrilesPyrazolesPyrimidinesNitrilesPyrazolesPyrimidinesruxolitinib

Identifiers

PMID29097381
PMCPMC5757682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.