Evidence map›Paper›PMID 29097299›Full record

ArticleContemporary clinical trials2018

The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.

Stephanie Alison Ward, Elsdon Storey, Robyn L Woods, Garun S Hamilton, Ryo Kawasaki, Andrew L Janke, Matthew T Naughton, Fergal O'Donoghue, Rory Wolfe, Tien Y Wong and 10 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01038583 (Aspirin in Reducing Events in the Elderly), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01038583 unknown statusnot on this map

Aspirin in Reducing Events in the Elderly

TypeobservationalSponsorHennepin Healthcare Research InstituteRan2010 to 2024Enrolled19,114ConditionsFunctional Disability, Dementia, Heart Disease, StrokeArms100 mg enteric-coated aspirin, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Development and Validation of Polygenic Scores for Retinal Vessel Calibers.Investigative ophthalmology & visual science · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 4 countries.

Stephanie Alison WardDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; Monash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia. Electronic address: Stephanie.Ward@monash.edu.
Elsdon StoreyDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; Department of Neuroscience (Medicine), Monash University, The Alfred Hospital, Commercial Rd, Melbourne 3004, Australia. Electronic address: elsdon.storey@monash.edu.
Robyn L WoodsDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: Robyn.Woods@monash.edu.
Garun S HamiltonDepartment of Lung and Sleep Medicine, Monash Health, 246 Clayton Rd, Clayton, Vic 3168, Australia; School of Clinical Sciences, Monash University, 246 Clayton Rd, Clayton, Vic 3168, Australia. Electronic address: Garun.Hamilton@monash.edu.
Ryo KawasakiDepartment of Vision Informatics (Topcon),Osaka University Graduate School of Medicine, E7 2-2 Yamada-oka, Suita-city, Osaka 565-1871, Japan. Electronic address: ryo.kawasaki@ophthal.med.osakau.ac.jp.
Andrew L JankeCentre for Advanced Imaging, University of Queensland, Building 57, Research Rd, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address: Andrew.janke@cai.uq.edu.au.
Matthew T NaughtonThe Department of Allergy, Immunology & Respiratory Medicine, Alfred Hospital, The Central Clinical School, Monash University, Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: M.Naughton@alfred.org.au.
Fergal O'DonoghueInstitute for Breathing and Sleep, Austin Health, Heidelberg, VIC 3084, Australia; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Vic, Australia. Electronic address: Fergal.ODonoghue@austin.org.au.
Rory WolfeDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: rory.wolfe@monash.edu.
Tien Y WongSingapore Eye Research Institute, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore; Duke-NUS Medical School, National University of Singapore, 8 College Rd, 169857, Singapore. Electronic address: Tien_yin_wong@nuhs.edu.sg.
Christopher M ReidDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; School of Public Health, Curtin University, Kent St, Bentley, Perth, WA 6102, Australia. Electronic address: chris.reid@monash.edu.
Walter P AbhayaratnaCollege of Medicine, Biology and Environment, Australian National University, Building 4, The Canberra Hospital, Hospital Rd, Garran ACT, Canberra 2605, Australia. Electronic address: Walter.P.Abhayaratna@act.gov.au.
Nigel StocksDiscipline of General Practice, Adelaide Medical School, University of Adelaide, Corner of North Terrace and George St, Adelaide, SA 5000, Australia. Electronic address: Nigel.stocks@adelaide.edu.au.
Ruth TrevaksDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: ruth.trevaks@monash.edu.
Sharyn FitzgeraldDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: sharyn.fitzgerald@monash.edu.
Lauren A B HodgsonCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia. Electronic address: labh@unimelb.edu.au.
Liubov RobmanDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia. Electronic address: liubov.robman@monash.edu.
Barbara WorkmanMonash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia. Electronic address: Barbara.Workman@monashhealth.org.
John J McNeilDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: john.mcneil@monash.edu.
ASPREE Study GroupThe ASPREE Study Group, Australia, USA.
Monash University · AUCurtin University · AUMonash Health · AUThe Alfred Hospital · AUAustralian National University · AUNational University of Singapore · SGThe University of Adelaide · AUThe University of Melbourne · AUThe University of Queensland · AUTopcon (Netherlands) · NL

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
NIA NIH HHS U01 AG029824
6 · The paper itself

Abstract

purposeSleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years.

designSNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. PRIMARY OUTCOME MEASURES: Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI.

conclusionIdentifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. SNORE-ASA

trial registrationACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.

Indexed as

AgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalAspirinCerebrovascular CirculationCognitionDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMental Status and Dementia TestsMicrovesselsMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicAnti-Inflammatory Agents, Non-SteroidalAspirinBrain magnetic resonance imagingCognitive declineDementiaLow-dose aspirinRetinal vascular imagingSleep disordered breathing

Identifiers

PMID29097299
PMCPMC6753831
OpenAlexW2766013582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.