ArticleBiochemical and biophysical research communications2018
Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells.
Article in Biochemical and biophysical research communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination.Nature communications · 2026Article
- ALKBH1 gene polymorphisms confer hepatoblastoma susceptibility in Chinese children.Scientific reports · 2026Article
- Current Insights into Obesity and mBiomedicines · 2025Review
- Review
- Insights into the role of RNA mGenes & diseases · 2024Review
- Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma.NAR cancer · 2024Article
- Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging.Cell proliferation · 2022Article
- RNA methylation in chloroplasts or mitochondria in plants.RNA biology · 2021Review
- Demethyltransferase AlkBH1 substrate diversity and relationship to human diseases.Molecular biology reports · 2021Review
- RNA mFrontiers in cell and developmental biology · 2021Review
- Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family.Cellular and molecular life sciences : CMLS · 2021Review
- NFrontiers in molecular biosciences · 2021Review
- AFF4 regulates osteogenic differentiation of human dental follicle cells.International journal of oral science · 2020Article
- Who Rules the Cell? An Epi-Tale of Histone, DNA, RNA, and the Metabolic Deep State.Frontiers in plant science · 2020Review
- Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogrammingRedox biology · 2020Article
- N 6-Hydroxymethyladenine: a hydroxylation derivative of N6-methyladenine in genomic DNA of mammals.Nucleic acids research · 2019Article
- Epitranscriptomic RNA Methylation in Plant Development and Abiotic Stress Responses.Frontiers in plant science · 2019Review
- The Role of m6A-Mediated DNA Damage Repair in Tumor Development and Chemoradiotherapy Resistance.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Alkbh1 is a mammalian homolog of the Escherichia coli DNA repair enzyme AlkB, an Fe(II) and 2-oxoglutarate dependent dioxygenase that removes alkyl lesions from DNA bases. The human homolog ALKBH1 has been associated with six different enzymatic activities including DNA, mRNA, or tRNA hydroxylation, cleavage at abasic (AP) sites in DNA, as well as demethylation of histones. The reported cellular roles of this protein reflect the diverse enzymatic activities and include direct DNA repair, tRNA modification, and histone modification. We demonstrate that ALKBH1 produced in mammalian cells (ALKBH1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.