Evidence map›Paper›PMID 29097123›Full record

ReviewEpilepsy & behavior : E&B2018

Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?

Helen E Scharfman, Andres M Kanner, Alon Friedman, Ingmar Blümcke, Candice E Crocker, Fernando Cendes, Ramon Diaz-Arrastia, Hans Förstl, André A Fenton, Anthony A Grace and 7 more

Open access · greenAbstract readReview
In one paragraph

Review in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Entropy of the resting state cortex in epilepsy.Biomedical physics & engineering express · 2026
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  7. The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 6 countries.

Helen E ScharfmanDepartments of Psychiatry, Neurosciences and Physiology, and the Neuroscience Institute, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address: hscharfman@nki.rfmh.org.
Andres M KannerUniversity of Miami, Miller School of Medicine, 1120 NW 14th Street, Room #1324, Miami, FL 33136, USA.
Alon FriedmanDepartment of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Department of Physiology and Cell Biology, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Ingmar BlümckeNeuropathological Institute, University Hospitals Erlangen, Germany.
Candice E CrockerNova Scotia Early Psychosis Program, Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Fernando CendesDepartment of Neurology, University of Campinas, 13083-888 Campinas, Sao Paulo, Brazil.
Ramon Diaz-ArrastiaCentre for Neuroscience & Regenerative Medicine, Uniformed Services University of the Health Sciences, 12725 Twinbrook Parkway, Rockville, MD 20852, USA.
Hans FörstlDepartment of Psychiatry, University of Munich, Klinikum rechts der Isar, Ismaninger Strabe 22, D-81675 Munich, Germany.
André A FentonCentre for Neural Science, New York University, 4 Washington Place, Room 809, New York, NY 10003, USA.
Anthony A GraceUniversity of Pittsburgh, 456 Langley Hall, 4200 Fifth Avenue, Pittsburgh, PA 15269, USA.
Jorge PalopDepartment of Neurology, Gladstone Institute, 1650 Owens Street, San Francisco, CA 94158-2261, USA.
Jason MorrisonDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Astrid NehligINSERM U 1129, Hôpital Necker, Paris, Faculty of Medicine, Strasbourg, France.
Asuri PrasadDepartment of Pediatrics, Children's Hospital of Western Ontario, London, ON, Canada.
Karen S WilcoxDepartment of Pharmacology & Toxicology, Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT, USA.
Nathalie JetteIcahn School of Medicine at Mount Sinai, Department of Neurology, New York, NY, USA; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Bernd Pohlmann-EdenBrain Repair Center, Life Science Research Institute, Dalhousie University, Room 229, PO Box 15000, Halifax, NS B3H4R2, Canada. Electronic address: B.Pohlmann-Eden@dal.ca.
Dalhousie University · CAChildren's Hospital of Western Ontario · CAGladstone Institutes · USHôpital Necker-Enfants Malades · FRIcahn School of Medicine at Mount Sinai · USLudwig-Maximilians-Universität München · DENew York University · USNYU Langone Health · USUniformed Services University of the Health Sciences · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Miami · USUniversity of Pittsburgh · USUniversity of Utah · US

Funding

The Role of Hippocampal area CA2 in EpilepsyR01NS106983 · NINDS · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Helen E Scharfman · 2018 to 2026
$4.9M
Hyperexcitability in Alzheimer's DiseaseR01AG055328 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2017 to 2021
$2.0M
Hilar mossy cells and dentate gyrus functionR01MH109305 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2016 to 2020
$2.0M
Diverse Roles of Adult Dentate Gyrus NeurogenesisR01NS081203 · NINDS · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 2013 to 2017
$1.8M
NIA NIH HHS R01 AG055328NIMH NIH HHS R01 MH109305NINDS NIH HHS R01 NS081203NINDS NIH HHS R01 NS106983
6 · The paper itself

Abstract

There is common agreement that many disorders of the central nervous system are 'complex', that is, there are many potential factors that influence the development of the disease, underlying mechanisms, and successful treatment. Most of these disorders, unfortunately, have no cure at the present time, and therapeutic strategies often have debilitating side effects. Interestingly, some of the 'complexities' of one disorder are found in another, and the similarities are often network defects. It seems likely that more discussions of these commonalities could advance our understanding and, therefore, have clinical implications or translational impact. With this in mind, the Fourth International Halifax Epilepsy Conference and Retreat was held as described in the prior paper, and this companion paper focuses on the second half of the meeting. Leaders in various subspecialties of epilepsy research were asked to address aging and dementia or psychosis in people with epilepsy (PWE). Commonalities between autism, depression, aging and dementia, psychosis, and epilepsy were the focus of the presentations and discussion. In the last session, additional experts commented on new conceptualization of translational epilepsy research efforts. Here, the presentations are reviewed, and salient points are highlighted.

Indexed as

SchizophreniaTranslational Research, BiomedicalDementiaEpilepsyHumansSchizophrenic PsychologyAlzheimer's diseaseCircuitNeurologyNeurosciencePreclinicalPsychosisSeizureSystems

Identifiers

PMID29097123
PMCPMC5756681
OpenAlexW2766523683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.