ArticleMolecular metabolism2017
Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal.
Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of exercise in a fed or fasted state on mitochondrial dynamics regulators in the skeletal muscle of recreationally active males.Experimental physiology · 2026Trial
- Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Mitochondrial quality control in human ageing and longevity.Nature metabolism · 2026Review
- From homeostasis to pathology, organelle-specific autophagy in skeletal muscle: a PRISMA-ScR scoping review.Frontiers in physiology · 2026Review
- Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse.Experimental physiology · 2025Review
- Tissue-specific responses to oxidative fuel source preference during heat stress in lactating dairy cows.JDS communications · 2025Article
- Mitochondrial Quantity and Quality in Age-Related Sarcopenia.International journal of molecular sciences · 2024Review
- Mitophagy in human health, ageing and disease.Nature metabolism · 2023Review
- Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review.Nutrients · 2023Review
- Insights into the development of insulin resistance: Unraveling the interaction of physical inactivity, lipid metabolism and mitochondrial biology.Frontiers in physiology · 2023Review
- The impact of diet upon mitochondrial physiology (Review).International journal of molecular medicine · 2022Review
- Targeting skeletal muscle mitochondrial health in obesity.Clinical science (London, England : 1979) · 2022Review
- Mitochondrial fusion- and fission-related protein expression in the regulation of skeletal muscle mass.Physiological reports · 2022Article
- Potential Role of Chronic Physical Exercise as a Treatment in the Development of Vitiligo.Frontiers in physiology · 2022Article
- Heat Stress Reduces Metabolic Rate While Increasing Respiratory Exchange Ratio in Growing Pigs.Animals : an open access journal from MDPI · 2021Article
- Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1Oxidative medicine and cellular longevity · 2021Article
- The effect of fasting or calorie restriction on mitophagy induction: a literature review.Journal of cachexia, sarcopenia and muscle · 2020Review
- Mechanisms of muscle insulin resistance and the cross-talk with liver and adipose tissue.Physiological reports · 2020Review
- Postprandial skeletal muscle metabolism following a high-fat diet in sedentary and endurance-trained males.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe tested the hypothesis that skeletal muscle of endurance-trained male runners would exhibit elevated autophagy and mitophagy markers, which would be associated with greater metabolic flexibility following a high-fat meal (HFM).
methodsMuscle biopsies were collected to determine differences in autophagy and mitophagy protein markers and metabolic flexibility under fasting conditions and 4 h following a HFM between endurance-trained male runners (n = 10) and sedentary, non-obese controls (n = 9).
resultsMaximal oxygen consumption (ml·kg·min
conclusionIn summary, mitophagy may be enhanced in endurance-trained runners based on elevated markers of mitophagy and mitochondrial dynamics. The HFM did not alter autophagy or mitophagy in either group. The absence of a relationship between mitophagy markers and metabolic flexibility suggests that mitophagy is not a key determinant of metabolic flexibility in a healthy population, but further investigation is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.