Trial reportBrazilian journal of anesthesiology (Elsevier)
[Comparison of postoperative analgesia with methadone versus morphine in cardiac surgery].
Trial report in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Efficacy and safety of intravenous methadone for pain management in cardiac surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Intravenous methadone for pain management in cardiac surgery: a randomised controlled trial with plasma concentration analysis.Anaesthesia · 2026Trial
- Multimodal Analgesia in Cardiothoracic Procedure: Opioid and Non-opioid Pharmacology for Pain Management: Part 1.Annals of cardiac anaesthesia · 2025Review
- Intraoperative methadone for postoperative pain in adult patients undergoing tonsillectomy-a randomised controlled trial.BJA open · 2025Article
- Article
- Optimizing Pain Management in Cardiac Surgery: A Review of Analgesic Adjuvants.Current pain and headache reports · 2024Review
- Methadone in combination with magnesium, ketamine, lidocaine, and dexmedetomidine improves postoperative outcomes after coronary artery bypass grafting: an observational multicentre study.Journal of cardiothoracic surgery · 2024Observational
- Article
- Article
- Effect of deuteration on the single dose pharmacokinetic properties and postoperative analgesic activity of methadone.Drug metabolism and pharmacokinetics · 2022Article
- Methadone for Pain Management: A Pharmacotherapeutic Review.CNS drugs · 2020Review
- The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials.Anesthesiology research and practice · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPain is an aggravating factor of postoperative morbidity and mortality. The aim of this study was to compare the effects of methadone versus morphine using the numerical rating scale of pain and postoperative on-demand analgesia in patients undergoing myocardial revascularization.
methodA randomized, double-blind, parallel clinical trial was performed with patients undergoing coronary artery bypass grafting. The subjects were randomly divided into two groups: Morphine Group (MoG) and Methadone Group (MeG). At the end of cardiac surgery, 0.1 mg.kg
resultsEach group comprised 50 patients. Methadone showed 22% higher efficacy than morphine as it yielded a number-needed-to-treat (NNT) score of 6 and number-needed-to-harm (NNH) score of 16. The MeG showed a mean score of 1.9 ±2.2 according to the numerical pain scale at 24hours after surgery, whereas as the MoG showed a mean score of 2.9 ±2.6 (p =0.029). The MeG required less morphine (29%) than the MoG (43%) (p =0.002). However, the time to first analgesic request in the postoperative period was 145.9 ±178.5 minutes in the MeG, and 269.4 ±252.9 in the MoG (p =0.005).
conclusionsMethadone was effective for analgesia in patients undergoing coronary artery bypass grafting without extracorporeal circulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.