Evidence map›Paper›PMID 29096718›Full record

ArticleBiology of sex differences2017

Stress amplifies sex differences in primate prefrontal profiles of gene expression.

Alex G Lee, Megan Hagenauer, Devin Absher, Kathleen E Morrison, Tracy L Bale, Richard M Myers, Stanley J Watson, Huda Akil, Alan F Schatzberg, David M Lyons

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alex G LeeDepartment of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd MSLS Room P104, Stanford, CA, 94305-5485, USA.
Megan HagenauerMolecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Kathleen E MorrisonDepartment of Animal Biology, University of Pennsylvania, Philadelphia, PA, USA.
Tracy L BaleDepartment of Animal Biology, University of Pennsylvania, Philadelphia, PA, USA.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Stanley J WatsonMolecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Huda AkilMolecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Alan F SchatzbergDepartment of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd MSLS Room P104, Stanford, CA, 94305-5485, USA.
David M LyonsDepartment of Psychiatry and Behavioral Sciences, Stanford University, 1201 Welch Rd MSLS Room P104, Stanford, CA, 94305-5485, USA. dmlyons@stanford.edu.
Stanford University · USUniversity of Michigan–Ann Arbor · USHudsonAlpha Institute for Biotechnology · USUniversity of Pennsylvania · US

Funding

MODEL OF HYPERCORTISOLISM FOR MAJOR DEPRESSIONSR01MH047573 · NIMH · STANFORD UNIVERSITY · PI SCHATZBERG, ALAN F. · 1991 to 2010
$5.3M
Can Affective Resilience be Enhanced? A Developmental and Epigenetic ApproachR01MH104261 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKIL, HUDA, WATSON, STANLEY J · 2014 to 2018
$2.8M
NIMH NIH HHS R01 MH047573NIMH NIH HHS R01 MH104261
6 · The paper itself

Abstract

backgroundStress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate sex differences and stress effects on prefrontal cortical profiles of gene expression in squirrel monkey adults.

methodsDorsolateral, ventrolateral, and ventromedial prefrontal cortical regions from 18 females and 12 males were collected after stress or no-stress treatment conditions. Gene expression profiles were acquired using HumanHT-12v4.0 Expression BeadChip arrays adapted for squirrel monkeys.

resultsExtensive variation between prefrontal cortical regions was discerned in the expression of numerous autosomal and sex chromosome genes. Robust sex differences were also identified across prefrontal cortical regions in the expression of mostly autosomal genes. Genes with increased expression in females compared to males were overrepresented in mitogen-activated protein kinase and neurotrophin signaling pathways. Many fewer genes with increased expression in males compared to females were discerned, and no molecular pathways were identified. Effect sizes for sex differences were greater in stress compared to no-stress conditions for ventromedial and ventrolateral prefrontal cortical regions but not dorsolateral prefrontal cortex.

conclusionsStress amplifies sex differences in gene expression profiles for prefrontal cortical regions involved in stress coping and emotion regulation. Results suggest molecular targets for new treatments of stress disorders in human mental health.

Indexed as

Gene ExpressionSex CharacteristicsAnimalsFemaleGene Expression ProfilingMalePrefrontal CortexSaimiriStress, PsychologicalGene expression profilingMAPK signalingNeurotrophinsPrefrontal cortexSex biasedSocial stressSquirrel monkeys

Identifiers

PMID29096718
PMCPMC5667444
OpenAlexW2765381695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.