ArticleParasites & vectors2017
Cutaneous leishmaniasis in northwestern Saudi Arabia: identification of sand fly fauna and parasites.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neglected Tropical Diseases (NTDs) in Saudi Arabia: Systematic Review and Meta-analysis.Journal of epidemiology and global health · 2025Pooled it
- Phlebotomine sand flies (Diptera: Psychodidae) of the Maghreb region: A systematic review of distribution, morphology, and role in the transmission of the pathogens.PLoS neglected tropical diseases · 2022Pooled it
- Role of Molecular Diagnosis in Imported Cutaneous Leishmaniasis and Its Public Health Significance in India.Pathogens (Basel, Switzerland) · 2025Article
- Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification ofFrontiers in microbiology · 2024Article
- Knowledge and Attitude Regarding Cutaneous Leishmaniasis Among Adult Population in Tabuk, Saudi Arabia.Cureus · 2024Article
- Molecular identification ofJournal of Taibah University Medical Sciences · 2023Article
- Seroprevalence of Toscana and sandfly fever Sicilian viruses in humans and livestock animals from western Saudi Arabia.One health (Amsterdam, Netherlands) · 2023Article
- Blood meal analysis and molecular detection of mammalian Leishmania DNA in wild-caught Sergentomyia spp. from Tunisia and Saudi Arabia.Parasitology research · 2023Article
- Cutaneous leishmaniasis in Tabuk, Saudi Arabia: epidemiological trends from 2006 to 2021.The Pan African medical journal · 2023Article
- Cutaneous Leishmaniasis: Associated Risk Factors and Prevention in Hubuna, Najran, Saudi Arabia.International journal of general medicine · 2023Article
- Molecular Characterization ofPathogens (Basel, Switzerland) · 2022Article
- Genotypic and phylogenic analyses of cutaneous leishmaniasis in Al Ahsa, Eastern Saudi Arabia during the coronavirus disease 2019 pandemic: First cases of Leishmania tropica with the predominance of Leishmania major.Scientific reports · 2022Article
- Analyzing the roles of some species of arthropods in the transmission of the Middle East respiratory syndrome coronavirus.Veterinary medicine and science · 2022Article
- Leishmaniasis: Recent epidemiological studies in the Middle East.Frontiers in microbiology · 2022Review
- Molecular characterization of Leishmania species from stray dogs and human patients in Saudi Arabia.Parasitology research · 2021Article
- Evolution, systematics and historical biogeography of sand flies of the subgenus Paraphlebotomus (Diptera, Psychodidae, Phlebotomus) inferred using restriction-site associated DNA markers.PLoS neglected tropical diseases · 2021Article
- The Geographical Distribution of Cutaneous Leishmaniasis Causative Agents in Iran and Its Neighboring Countries, A Review.Frontiers in public health · 2020Review
- Prevalence of Leishmania species among patients with cutaneous leishmaniasis in Qassim province of Saudi Arabia.BMC public health · 2019Article
- Prevalence of Cutaneous Leishmaniasis in Western Highlands in Yemen.Journal of tropical medicine · 2019Article
- Development of a Diagnostic Marker forInsects · 2018Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCutaneous leishmaniasis (CL) is a vector-borne disease transmitted by the bite of an infected sand fly. This disease is highly prevalent in Saudi Arabia where Leishmania major and L. tropica are the etiological agents. In the region of Hail, northwestern of Saudi Arabia, the incidence is about 183 cases/year. However, the epidemiology of the disease in this area is not well understood. Thus, an epidemiological survey was conducted in 2015-2016 to identify the circulating parasite and the sand fly fauna in the region of Hail. Skin lesion scrapings were collected from suspected patients with CL.
methodsThe diagnosis was made by microscopic examination of Giemsa-stained smear and PCR. The parasite was identified by PCR and sequencing of the single copy putative translation initiation factor alpha subunit gene. Sand fly specimens were collected and identified morphologically. Total DNA was extracted from the abdomen of female specimens and Leishmania DNA was detected by PCR.
resultsAmong the 57 examined patients, 37 were positive for CL. The identification of the parasite has revealed the single species Leishmania major. The 384 sand flies were collected belonged to two genera (Phlebotomus and Sergentomyia), six sub-genera and six species. Phlebotomus papatasi, Ph. kazeruni and Sergentomyia clydei were the dominant species. Leishmania DNA was detected in two females of Ph. papatasi two of Ph. kazeruni and one specimen of Sergentomyia clydei.
conclusionsLeishmania major is confirmed to be the etiological agent of cutaneous leishmaniasis in northwestern Saudi Arabia. The molecular detection of Leishmania DNA in Ph. papatasi and Ph. kazeruni supports the potential role of these two species in the transmission of Leishmania. Further epidemiological studies are needed to prove their role and to evaluate the burden of CL in the study region.
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