Evidence map›Paper›PMID 29096160›Full record

ArticleVirology2018

MMTV does not encode viral microRNAs but alters the levels of cancer-associated host microRNAs.

Rodney P Kincaid, Neena G Panicker, Mary M Lozano, Christopher S Sullivan, Jaquelin P Dudley, Farah Mustafa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Mouse Mammary Tumor Virus (MMTV)-LikeInternational journal of environmental research and public health · 2020
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rodney P KincaidDepartment of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America. Electronic address: rpkincaid@gmail.com.
Neena G PanickerDepartment of Biochemistry, College of Medicine and Health Sciences, UAE University, Tawam Hospital Complex, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: ngpanicker@uaeu.ac.ae.
Mary M LozanoDepartment of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America. Electronic address: mlozano@austin.utexas.edu.
Christopher S SullivanDepartment of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America. Electronic address: chris_sullivan@austin.utexas.edu.
Jaquelin P DudleyDepartment of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America. Electronic address: jdudley@austin.utexas.edu.
Farah MustafaDepartment of Biochemistry, College of Medicine and Health Sciences, UAE University, Tawam Hospital Complex, P.O. Box 17666, Al Ain, United Arab Emirates. Electronic address: fmustafa@uaeu.ac.ae.
The University of Texas at Austin · USTawam Hospital · AE

Funding

Retroviral Subversion of ERAD and Intrinsic ImmunityR01CA167053 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI DUDLEY, JAQUELIN PAGE · 2012 to 2016
$1.8M
NCI NIH HHS R01 CA167053
6 · The paper itself

Abstract

Mouse mammary tumor virus (MMTV) induces breast cancer in mice in the absence of known virally-encoded oncogenes. Tumorigenesis by MMTV is thought to occur primarily through insertional mutagenesis, leading to the activation of cellular proto-oncogenes and outgrowth of selected cells. Here we investigated whether MMTV encodes microRNAs (miRNAs) and/or modulates host miRNAs that could contribute to tumorigenesis. High throughput small RNA sequencing analysis of MMTV-infected cells and MMTV-induced mammary tumors demonstrates that MMTV does not encode miRNAs. However, infected tissues have altered levels of several host miRNAs, including increased expression of members of the oncogenic miRNA cluster, miR-17-92. Notably, similar changes in miRNA levels have been previously reported in human breast cancers. Combined, our results demonstrate that virally encoded miRNAs do not contribute to MMTV-mediated tumorigenesis, but that changes in specific host miRNAs in infected cells may contribute to virus replication and tumor biology.

Indexed as

Gene Expression RegulationHost-Pathogen InteractionsAnimalsHigh-Throughput Nucleotide SequencingMammary Neoplasms, ExperimentalMammary Tumor Virus, MouseMiceMicroRNAsMicroRNAsBreast cancermicroRNAs (miRNAs)miR-17–92 clusterMouse mammary tumor virus (MMTV)RetrovirusesVirus-host interactions

Identifiers

PMID29096160
PMCPMC6258203
OpenAlexW2766669327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.