Evidence map›Paper›PMID 29096072›Full record

ReviewNeuron2017

The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas.

Joseph R Ecker, Daniel H Geschwind, Arnold R Kriegstein, John Ngai, Pavel Osten, Damon Polioudakis, Aviv Regev, Nenad Sestan, Ian R Wickersham, Hongkui Zeng

Abstract readReview
In one paragraph

Review in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Decoding Alzheimer's Disease One Cell Class at a Time.Cellular and molecular neurobiology · 2026
    Review
  6. Review
  7. Article
  8. Neural Immunoglobulins Shape Brain Circuits.The European journal of neuroscience · 2025
    Review
  9. Article
  10. Strategies to Decipher Neuron Identity from Extracellular Recordings in Behaving Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. WashU Epigenome Browser update 2025.Nucleic acids research · 2025
    Article
  12. Review
  13. Spatial Multiomics Toward Understanding Neurological Systems.Journal of mass spectrometry : JMS · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph R EckerGenomic Analysis Laboratory and Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Daniel H GeschwindProgram in Neurogenetics, Departments of Neurology and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Arnold R KriegsteinEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
John NgaiDepartment of Molecular and Cell Biology, Helen Wills Neuroscience Institute, QB3 Functional Genomics Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: jngai@berkeley.edu.
Pavel OstenCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Damon PolioudakisProgram in Neurogenetics, Departments of Neurology and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Department of Biology, Koch Institute of Integrative Cancer Research, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Nenad SestanDepartments of Neuroscience, Genetics, Psychiatry and Comparative Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale Child Study Center, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT 06510, USA.
Ian R WickershamMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, PACHTER, LIOR S · 2017 to 2021
$64.7M
Collaboratory for atlasing cell type anatomy in the female and male mouse brainU01MH114824 · NIMH · COLD SPRING HARBOR LABORATORY · PI MITRA, PARTHA PRATIM · 2017 to 2021
$11.7M
Mapping the Developing Human Neocortex by Massively Parallel Single Cell AnalysisU01MH105989 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD · 2014 to 2016
$5.1M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
A Novel Approach for Cell-Type Classification and Connectivity in the Human BrainU01MH105972 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2016
$4.9M
Classification of Cortical Neurons by Single Cell TranscriptomicsU01MH105979 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2014 to 2016
$4.5M
Comprehensive Classification Of Neuronal Subtypes By Single Cell TranscriptomicsU01MH105960 · NIMH · HARVARD UNIVERSITY · PI REGEV, AVIV, SANES, JOSHUA R · 2014 to 2016
$4.5M
Towards quantitative cell type-based mapping of the whole mouse brainU01MH105971 · NIMH · COLD SPRING HARBOR LABORATORY · PI OSTEN, PAVEL · 2014 to 2016
$3.9M
Epigenomic mapping approaches for cell-type classification in the brainU01MH105985 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BEHRENS, M MARGARITA, ECKER, JOSEPH R · 2014 to 2016
$3.3M
Defining cell types, lineage, and connectivity in developing human fetal cortexU01MH105991 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2014 to 2016
$2.0M
NIMH NIH HHS U01 MH105960NIMH NIH HHS U01 MH105971NIMH NIH HHS U01 MH105972NIMH NIH HHS U01 MH105979NIMH NIH HHS U01 MH105982NIMH NIH HHS U01 MH105985NIMH NIH HHS U01 MH105989NIMH NIH HHS U01 MH105991NIMH NIH HHS U01 MH114824NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot projects funded by the U.S. BRAIN Initiative, in developing, validating, and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans.

Indexed as

Atlases as TopicAnimalsBrainBrain MappingHumansNerve NetPilot ProjectsanatomyBRAIN initiativecell censusconnectivityelectrophysiologyhuman brainmouse brainsingle-cell epigenomicssingle-cell RNA-seqsingle-cell transcriptomics

Identifiers

PMID29096072
PMCPMC5689454

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.