Evidence map›Paper›PMID 29096071›Full record

ReviewNeuron2017

Molecular Neuroscience in the 21

Thomas C Südhof

Abstract readReview
In one paragraph

Review in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Biogenesis and reformation of synaptic vesicles.The Journal of physiology · 2025
    Review
  3. Review
  4. Understanding the molecular diversity of synapses.Nature reviews. Neuroscience · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. S-SCAM is essential for synapse formation.Frontiers in cellular neuroscience · 2023
    Article
  9. Bound CaFrontiers in physiology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Thomas C SüdhofDepartment of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, 265 Campus Drive, CA 94305-5453, USA. Electronic address: tcs1@stanford.edu.

Funding

Role of synaptotagmins and neurexin ligands in homeostatic synaptic plasticityP50MH086403 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2009 to 2019
$18.4M
FUNCTION OF NEUREXINSR37MH052804 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SUDHOF, THOMAS C. · 2000 to 2019
$9.3M
Mouse CoreP50NS094733 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHEN, JIE · 2015 to 2020
$7.1M
NIMH NIH HHS P50 MH086403NIMH NIH HHS R37 MH052804NINDS NIH HHS P50 NS094733
6 · The paper itself

Abstract

Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits.

Indexed as

AnimalsBrainHumansNeurobiologyNeuronal PlasticityNeurosciencescytoskeletonmemorymicrogliamicrovasculatureneural circuitneuropeptidesspinesynapse formationsynaptic plasticitysynaptic transmission

Identifiers

PMID29096071
PMCPMC5689449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.