Evidence map›Paper›PMID 29096048›Full record

ArticleBiometrics2018

Reader Reaction: A note on testing and estimation in marker-set association study using semiparametric quantile regression kernel machine.

Xiang Zhan, Michael C Wu

Abstract readComment
In one paragraph

Article in Biometrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Xiang ZhanPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, U.S.A.ORCID 0000-0001-9650-143X
Michael C WuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, U.S.A.

Funding

SWOG Statistics & Data Management Center complex - extension supplement for GY06U10CA180819 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MEGAN OTHUS · 2014 to 2026
$115.2M
Enhanced Gene Identification in Complex Traits Using Kernel MachinesR01HG007508 · NHGRI · EMORY UNIVERSITY · PI EPSTEIN, MICHAEL PHILIP · 2013 to 2015
$1.0M
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
NCI NIH HHS U10 CA180819NHGRI NIH HHS R01 HG007508NIH HHS S10 OD020069
6 · The paper itself

Abstract

Kong et al. (2016, Biometrics 72, 364-371) presented a quantile regression kernel machine (QRKM) test for robust analysis of genetic marker-set association studies. A potential limitation of QRKM is the permutation-based test design may be unscalable for the massive sizes of modern datasets. In this article, we present an alternative strategy for p-value calculation of QRKM, which is capable of speeding up the QRKM testing procedure dramatically while maintaining the same testing performance as QRKM. The effectiveness of our approach is demonstrated via simulation studies.

Indexed as

Computer SimulationModels, StatisticalBiomarkersBiometryGenetic Association StudiesBiomarkersFast permutation testGenetic marker-set associationKernel machinesQuantile regression

Identifiers

PMID29096048
PMCPMC5932287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.