ArticlePloS one2017
Adverse drug events in German hospital routine data: A validation of International Classification of Diseases, 10th revision (ICD-10) diagnostic codes.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Electronic health record-based prediction models for in-hospital adverse drug event diagnosis or prognosis: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2023Pooled it
- Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage.European journal of clinical pharmacology · 2022Pooled it
- The use of international classification of diseases codes to identify hospital admissions linked with adverse drug events: Validation study.British journal of clinical pharmacology · 2025Article
- A scoping review of the methodological approaches used in retrospective chart reviews to validate adverse event rates in administrative data.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2024Article
- International Trends in Adverse Drug Event-Related Mortality from 2001 to 2019: An Analysis of the World Health Organization Mortality Database from 54 Countries.Drug safety · 2024Observational
- Higher Odds of Adverse Cutaneous Reactions in Patients With Dermatomyositis Treated With Hydroxychloroquine Compared With Methotrexate.ACR open rheumatology · 2023Article
- Validating ICD-10 codes for adverse drug events in hospitalised older adults: protocol for a cross-sectional study.BMJ open · 2022Article
- Evaluation of Factors Associated with Adverse Drug Events in South Korea Using a Population-Based Database.Journal of clinical medicine · 2022Article
- Shortcomings of Administrative Data to Derive Preventive Strategies for Inhospital Drug-Induced Acute Kidney Failure-Insights from Patient Record Analysis.Journal of clinical medicine · 2022Article
- Intelligent Telehealth in Pharmacovigilance: A Future Perspective.Drug safety · 2022Review
- Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data.Revista de saude publica · 2022Article
- Exploring the prevalence and characteristics of adverse drug events among older adults in South Korea using a national health insurance database.Frontiers in pharmacology · 2022Article
- Comparing the dangers of a stay in English and German hospitals for high-need patients.Health services research · 2021Article
- Development of measurable criteria to identify and prioritize patients for inclusion in comprehensive medication management programs within primary care settings.Journal of managed care & specialty pharmacy · 2021Article
- Detection of adverse drug events in e-prescribing and administrative health data: a validation study.BMC health services research · 2021Article
- Identifying medication harm in hospitalised patients: a bimodal, targeted approach.Therapeutic advances in drug safety · 2020Article
- Improving drug safety in hospitals: a retrospective study on the potential of adverse drug events coded in routine data.BMC health services research · 2019Observational
- A comparison of two structured taxonomic strategies in capturing adverse events in U.S. hospitals.Health services research · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdverse drug events (ADEs) during hospital stays are a significant problem of healthcare systems. Established monitoring systems lack completeness or are cost intensive. Routinely assigned International Statistical Classification of Diseases and Related Health Problems (ICD) codes could complement existing systems for ADE identification. To analyze the potential of using routine data for ADE detection, the validity of a set of ICD codes was determined focusing on hospital-acquired events. MATERIAL AND
methodsThe study utilized routine data from four German hospitals covering the years 2014 and 2015. A set of ICD, 10th Revision, German Modification (ICD-10-GM) diagnoses coded most frequently in the routine data and identified as codes indicating ADEs was analyzed. Data from psychiatric and psychotherapeutic departments were excluded. Retrospective chart review was performed to calculate positive predictive values (PPV) and sensitivity.
resultsOf 807 reviewed ADE codes, 91.2% (95%-confidence interval: 89.0, 93.1) were identified as disease in the medical records and 65.1% (61.7, 68.3) were confirmed as ADE. For code groups being predominantly hospital-acquired, 78.5% (73.7, 82.9) were confirmed as ADE, ranging from 68.5% to 94.4% dependent on the ICD code. However, sensitivity of inpatient ADEs was relatively low. 49.7% (45.2, 54.2) of 495 identified hospital-acquired ADEs were coded as disease in the routine data, from which a subgroup of 12.1% (9.4, 15.3) was coded as drug-associated disease.
conclusionsICD codes from routine data can provide an important contribution to the development and improvement of ADE monitoring systems. Documentation quality is crucial to further increase the PPV, and actions against under-reporting of ADEs in routine data need to be taken.
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