ArticlePloS one2017
The association between tinnitus and the risk of ischemic cerebrovascular disease in young and middle-aged patients: A secondary case-control analysis of a nationwide, population-based health claims database.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Association Between Tinnitus and Angina Pectoris in U.S. Adults: Evidence from NHANES 2009-2018.Audiology research · 2026Article
- Tinnitus is not associated with cardiovascular risk factors or mortality in the Gutenberg Health Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Anti-neuroinflammatory therapy for non-pulsatile tinnitus in patients with sinus vascular anomalies: preliminary result on two cases.Frontiers in neurology · 2025Article
- Tinnitus and cardiovascular disease: the population-based Tromsø Study (2015-2016).BMJ public health · 2024Article
- Tinnitus Prevalence, Associated Characteristics, and Treatment Patterns among Adults in Saudi Arabia.Audiology research · 2024Article
- Disabling tinnitus and third nerve palsy following pontine hemorrhage: Application of ICF framework.Clinical case reports · 2024Article
- Article
- Prevalence of Tinnitus and Its Associated Factors in the PERSIAN Guilan Cohort Study.Iranian journal of otorhinolaryngology · 2023Article
- Relationship between tinnitus and headache in Riyadh, Saudi Arabia.Journal of family medicine and primary care · 2022Article
- Tinnitus and Neuropsychological Dysfunction in the Elderly: A Systematic Review on Possible Links.Journal of clinical medicine · 2021Review
- Association of Tinnitus with Depression in a Normal Hearing Population.Medicina (Kaunas, Lithuania) · 2021Article
- Analysis of the audiological characteristics and comorbidity in patients with chronic tinnitus.Audiology research · 2019Article
- Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach.The EPMA journal · 2019Review
- Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTinnitus and ischemic cerebrovascular disease (ICVD) may share common pathophysiologic mechanisms. Nevertheless, no studies have investigated whether tinnitus is associated with a higher risk of ICVD. The aim of this study was to evaluate the risk of ICVD among young and middle-aged patients with tinnitus.
methodsUsing the Taiwan's National Health Insurance Research Database, we identified 3,474 patients 20-45 years old with incident ICVD diagnosed between January 1, 2000 and December 31, 2010 and 17,370 controls, frequency matched on age interval, sex, and year of the index date. Risk of ICVD associated with tinnitus was assessed using multiple logistic regression analyses.
resultsTinnitus was significantly associated with a higher risk of incident ICVD among young and middle-aged patients (adjusted odds ratio [OR] 1.66, 95% confidence interval [CI] 1.34-2.04), adjusting for sex, age, and comorbidities. In addition, sex-stratified analysis showed that the associations were significant in both male (adjusted OR 1.55, 95% CI 1.16-2.07) and female patients (adjusted OR 1.77, 95% CI 1.30-2.41). Furthermore, tinnitus was significantly associated with a higher risk of ICVD in the 20.0-29.9 years (adjusted OR 4.11, 95% CI 1.98-8.52) and 30.0-39.9 years (adjusted OR 2.19, 95% CI 1.57-3.05) age groups, but not in the 40.0-45.0 years age group.
conclusionsTinnitus could be a novel risk factor or clinical indicator for young ischemic stroke, and further investigations are warranted.
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