Evidence map›Paper›PMID 29095870›Full record

SynthesisPloS one2017

Accuracy of a screening tool for medication adherence: A systematic review and meta-analysis of the Morisky Medication Adherence Scale-8.

Sun Jae Moon, Weon-Young Lee, Jin Seub Hwang, Yeon Pyo Hong, Donald E Morisky

Erratum issued 2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 121 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05010317 nacompletednot on this mapstarted 2022, after this paper: background citation

Acceptability, Feasibility and Effectiveness of a Mindfulness Based Intervention to Promote Adherence to Antiretroviral Therapy Among Adolescents in Kampala.

TypeinterventionalSponsorInfectious Diseases Research Collaboration, UgandaRan2022 to 2023Enrolled122ConditionsMedication Adherence, Adjustment Reaction With Anxiety and Depression, Mental Health IssueArmsMindfulness and acceptance based therapy, Standard of care
NCT06630715 recruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy Of Upadacitinib In Psoriatic Arthritis And Comparison To Rheumatoid Arthritis. OPTimising IMAging For The Use In The Follow-Up Of Arthritis: The OPTIMA Study

TypeobservationalSponsorI.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioRan2024 to 2025Enrolled178ConditionsRheumatoid Arthritis (RA, Psoriatic Arthritis (PsAArmsUpadacitinib 15 MG [Rinvoq]
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sun Jae MoonDepartment of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Weon-Young LeeDepartment of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-3062-3973
Jin Seub HwangDepartment of Computer science and Statistics, Daegu University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea.
Yeon Pyo HongDepartment of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Donald E MoriskyDepartment of Community Health Sciences UCLA Fielding School of Public Health, Los Angeles, California, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis systematic review examined the reliability and validity of the Morisky Medication Adherence Scale-8 (MMAS-8), which has been widely used to assess patient medication adherence in clinical research and medical practice.

methodsOf 418 studies identified through searching 4 electronic databases, we finally analyzed 28 studies meeting the selection criteria of this study regarding the reliability and validity of MMAS-8 including sensitivity and specificity. Meta-analysis for Cronbach's α, intraclass correlation coefficient (ICC), sensitivity and specificity to detect a patient with nonadherence to medication were performed. The pooled estimates for Cronbach's α and ICC were calculated using the random-effects weighted T transformation. A bivariate random-effects model was used to estimate pooled sensitivity and specificity.

findingsThe pooled Cronbach's α estimate for type 2 diabetes group in 7 studies and osteoporosis group in 3 studies were 0.67 (95% Confidence Interval(CI), 0.65 to 0.69) and 0.77 (95% CI, 0.72 to 0.83), respectively. With regard to test-retest, the pooled ICC for type 2 diabetes group in 3 studies and osteoporosis group in 2 studies were 0.81 (95% CI, 0.75 to 0.85) and 0.80 (95% CI, 0.74 to 0.85). For a cut-off value of 6, the pooled sensitivity and specificity in 12 studies were 0.43 (95% CI, 0.33 to 0.53) and 0.73 (95% CI, 0.68 to 0.78), respectively.

conclusionsThe MMAS-8 had acceptable internal consistency and reproducibility in a few diseases like type 2 diabetes. Using the cut-off value of 6, criterion validity was not enough good to validly screen a patient with nonadherence to medication. However, this study did not calculated a pooled estimate for criterion validity using the higher values than 6 as a cut-off value since most of included individual studies did not report criterion validity based on those values.

Indexed as

Drug TherapyPatient ComplianceHumansReproducibility of Results

Identifiers

PMID29095870
PMCPMC5667769

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.