Evidence map›Paper›PMID 29095833›Full record

ArticlePloS one2017

Texture analysis of acute myocardial infarction with CT: First experience study.

Ricarda Hinzpeter, Matthias W Wagner, Moritz C Wurnig, Burkhardt Seifert, Robert Manka, Hatem Alkadhi

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Predicting Chronic Myocardial Ischemia Using CCTA-Based Radiomics Machine Learning Nomogram.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
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  4. Prognostic value of SPECT myocardial perfusion entropy in high-risk type 2 diabetic patients.European journal of nuclear medicine and molecular imaging · 2021
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  16. Radiomics in Cardiac Computed Tomography.Diagnostics (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ricarda HinzpeterInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Matthias W WagnerInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Moritz C WurnigInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Burkhardt SeifertEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Robert MankaInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Hatem AlkadhiInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2581-2166
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the feasibility and accuracy of texture analysis to distinguish through objective and quantitative image information between healthy and infarcted myocardium with computed tomography (CT). MATERIALS AND

methodsTwenty patients (5 females; mean age 56±10years) with proven acute myocardial infarction (MI) and 20 patients (8 females; mean age 42±15years) with no cardiac abnormalities (hereafter termed controls) underwent contrast-enhanced cardiac CT. Short axis CT images of the left ventricle (LV) were reconstructed at the slice thicknesses 1mm, 2mm, and 5mm. Two independent, blinded readers segmented the LV in controls and patients. Texture analysis was performed yielding first-level features based on the histogram (variance, skewness, kurtosis, entropy), second-level features based on the gray-level co-occurrence matrix (GLCM) (contrast, correlation, energy and homogeneity), and third-level features based on the gray-level run-length matrix (GLRLM).

resultsInter-and intrareader agreement was good to excellent for all histogram (intraclass correlation coefficient (ICC):0.70-0.93) and for all GLCM features (ICC:0.66-0.99), and was variable for the GLRLM features (ICC:-0.12-0.99). Univariate analysis showed significant differences between patients and controls for 2/4 histogram features, 3/4 GLCM and for 6/11 GLRLM features and all assessed slice thicknesses (all,p<0.05). In a multivariate logistic regression model, the single best variable from each level, determined by ROC analysis, was included stepwise. The best model included kurtosis (OR 0.08, 95%CI:0.01-0.65,P = 0.018) and short run high gray-level emphasis (SRHGE, OR 0.97, 95%CI:0.94-0.99,P = 0.007), with an area-under-the-curve (AUC) of 0.90 (95%CI:0.80-0.99). The best results for kurtosis and SRHGE (AUC = 0.78) were obtained at a 5mm slice thickness. A cut-off value of 14.4 for kurtosis+0.013*SRHGE predicted acute MI with a sensitivity of 95% (specificity 55%).

conclusionOur study illustrates the feasibility of texture analysis for distinguishing healthy from acutely infarcted myocardium with cardiac CT using objective, quantitative features, with most reproducible and accurate results at a short axis slice thickness of 5mm.

Indexed as

AdultAgedContrast MediaFemaleHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionTomography, X-Ray ComputedContrast Media

Identifiers

PMID29095833
PMCPMC5667797
OpenAlexW2765597040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.