ArticleJournal of the American Geriatrics Society2017
Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions: A Cohort Study.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03682081 (Impact of Novel Rehabilitative Approaches for Dysphagia in Patients With Alzheimer's Disease and Related Dementias), which is not on this map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Novel Rehabilitative Approaches for Dysphagia in Patients With Alzheimer's Disease and Related Dementias
Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan.PloS one · 2021Trial
- Fatal Choking in Patients with Psychiatric Disorders: A Systematic Review of Forensic Evidence.Diagnostics (Basel, Switzerland) · 2026Review
- Individualized Medication Selection and Outcome Prediction for Patients With Dementia and BPSD Based on Systemic Immune-Inflammation Index (SII): A Retrospective Case-Control Study.Actas espanolas de psiquiatria · 2026Article
- Disparities in Physical Restraints and Antipsychotic use in Hospitalized Patients with Limited English Proficiency.Journal of general internal medicine · 2026Article
- Association of Aspiration Pneumonia-Related Factors with the Incidence of Healthcare-Associated Pneumonia in Elderly with Dementia.Journal of clinical medicine · 2025Article
- Advances in Understanding Recurrent Pulmonary Infections Following Foreign Body Aspiration: A Narrative Review.Journal of asthma and allergy · 2025Review
- Association between hospital palliative care team intervention volume and patient outcomes.International journal of clinical oncology · 2024Article
- Association of pneumonia admission with polypharmacy and drug use in community-dwelling older people.Geriatrics & gerontology international · 2024Article
- Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.Annals of internal medicine · 2023Article
- Acute Antipsychotic Use and Presence of Dysphagia Among Older Veterans with Heart Failure.Journal of the American Medical Directors Association · 2023Article
- Pharmacotherapy in autism spectrum disorders, including promising older drugs warranting trials.World journal of psychiatry · 2023Review
- The effect of polypharmacy on healthcare services utilization in older adults with comorbidities: a retrospective cohort study.BMC primary care · 2023Article
- Mortality rates and proximal causes of death in patients with Lewy body dementia versus Alzheimer's disease: A longitudinal study using secondary care mental health records.International journal of geriatric psychiatry · 2023Article
- Comprehensive Approaches to Aspiration Pneumonia and Dysphagia in the Elderly on the Disease Time-Axis.Journal of clinical medicine · 2022Review
- The Association Between Antihypertensive Drug Use and Hospitalization for Pneumonia in the General Population: A Case-Crossover Study Using the National Health Insurance Database of Korea.Journal of Korean medical science · 2022Article
- Article
- Association Between Antihypertensive Use and Hospitalized Pneumonia in Patients With Stroke: A Korean Nationwide Population-Based Cohort Study.Journal of Korean medical science · 2022Article
- Aspiration pneumonia.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Review
- Aspiration syndromes and associated lung injury: incidence, pathophysiology and management.Physiological research · 2021Review
- Psychotropic Drug-Associated Pneumonia in Older Adults.Drugs & aging · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesOff-label use of antipsychotics is common in hospitals, most often for delirium management. Antipsychotics have been associated with aspiration pneumonia in community and nursing home settings, but the association in hospitalized individuals is unexplored. We aimed to investigate the association between antipsychotic exposure and aspiration pneumonia during hospitalization.
designRetrospective cohort study.
settingLarge academic medical center.
participantsAll adult hospitalizations between January 2007 and July 2013. We excluded outside hospital transfers, hospitalizations shorter than 48 hours, and psychiatric hospitalizations. MEASUREMENTS: Antipsychotic use defined as any pharmacy charge for an antipsychotic medication. Aspiration pneumonia was defined according to a discharge diagnosis code for aspiration pneumonia not present on admission and validated using chart review. A generalized estimating equation was used to control for 43 potential confounders.
resultsOur cohort included 146,552 hospitalizations (median age 56; 39% male). Antipsychotics were used in 10,377 (7.1%) hospitalizations (80% atypical, 35% typical, 15% both). Aspiration pneumonia occurred in 557 (0.4%) hospitalizations. The incidence of aspiration pneumonia was 0.3% in unexposed individuals and 1.2% in those with antipsychotic exposure (odds ratio (OR) = 3.9, 95% confidence interval (CI) = 3.2-4.8). After adjustment, antipsychotic exposure was significantly associated with aspiration pneumonia (adjusted OR = (aOR) = 1.5, 95% CI = 1.2-1.9). Similar results were demonstrated in a propensity-matched analysis and in an analysis restricted to those with delirium or dementia. The magnitude of the association was similar for typical (aOR = 1.4, 95% CI = 0.94-2.2) and atypical (aOR = 1.5, 95% CI = 1.1-2.0) antipsychotics.
conclusionAntipsychotics were associated with greater odds of aspiration pneumonia after extensive adjustment for participant characteristics. This risk should be considered when prescribing antipsychotics in the hospital.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.