Evidence map›Paper›PMID 29095422›Full record

ArticleJournal of clinical gastroenterology2018

Roles of High-resolution Manometry in Predicting Incomplete Bolus Transit in Patients With Dysphagia.

Zhaohong Shi, Jie Guo, John Clarke, Haifeng Jin, Xinjun Wang, Nina Zhang, Ellen Stein, Sameer Dhalla, Pankaj J Pasricha, Jiande D Z Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhaohong ShiDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Jie GuoDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
John ClarkeDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Haifeng JinDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Xinjun WangDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Nina ZhangDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Ellen SteinDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Sameer DhallaDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Pankaj J PasrichaDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Jiande D Z ChenDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD.
Zhejiang Chinese Medical University · CN

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
NIDDK NIH HHS P30 DK089502
6 · The paper itself

Abstract

backgroundHigh-resolution manometry (HRM) is used to assess esophageal motility diseases. Abnormalities in a number of HRM parameters have been reported in patients with dysphagia. However, it is unclear whether some of abnormal HRM parameters are predictive of dysphagia. The aim of this retrospective study was to investigate the roles of HRM parameters in predicting incomplete bolus clearance (IBC) in patients with dysphagia using high-resolution impedance manometry.

methodsA total of 644 wet swallows were reviewed and analyzed in 63 patients with symptoms of dysphagia or reflux who underwent a clinical high-resolution impedance manometry test. IBC was defined based on impedance measurement. The relationship of each of abnormal HRM parameters with IBC was analyzed and their roles in predicting IBC were determined.

resultsPatients with symptoms of both dysphagia and reflux showed the highest IBC rate, and patients with symptoms of reflux had the lowest IBC rate. The IBC was more prevalent in the distal esophagus. Premature contractions and peristalsis with large breaks were associated with a higher IBC rate in the proximal esophagus (P<0.05); large breaks, ineffective peristalsis, and abnormalities of the esophageal gastric junction functions were associate with higher IBC rates in the distal esophagus (P<0.05). Abnormalities in a number of motility parameters were able to predict IBC with high specificities and/or high sensitivity, such as pan esophageal pressurization, ineffective peristalsis, and large breaks. Abnormal integrative relaxation pressure of the lower esophageal sphincter with concurrent pan esophageal pressurization, ineffective peristalsis, or large breaks is predictive of IBC with nearly 100% of specificity.

conclusionsAbnormalities in a number of HRM parameters are not only useful in diagnosing esophageal motility diseases, but also valuable in predicting IBC during swallowing.

Indexed as

AdolescentAdultAgedDeglutition DisordersElectric ImpedanceEsophageal Motility DisordersFemaleGastroesophageal RefluxGastrointestinal TransitHumansMaleManometryMiddle AgedPeristalsisPredictive Value of TestsRetrospective Studies

Identifiers

PMID29095422
PMCPMC6454548
OpenAlexW2765539197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.