Evidence map›Paper›PMID 29095379›Full record

Trial reportNursing research

Using Functional Connectivity Magnetic Resonance Imaging to Measure Brain Connectivity in Preterm Infants.

Rita Pickler, Stephanie Sealschott, Margo Moore, Stephanie Merhar, Jean Tkach, Andrew P Salzwedel, Weili Lin, Wai Gao

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Rita PicklerRita Pickler, PhD, RN, FAAN, is the FloAnn Sours Easton Professor of Child and Adolescent Health and Director, PhD and MS in Nursing Science Programs, College of Nursing, The Ohio State University, Columbus. Stephanie Sealschott, BS, RN, is T32 Predoctoral Fellow, College of Nursing, The Ohio State University, Columbus, and Research Nurse I, Cincinnati Children's Hospital Medical Center, Ohio. Margo Moore, MS, RN, is Research Nurse III, Cincinnati Children's Hospital Medical Center, Ohio. Stephanie Merhar, MD, MS, is Attending Neonatologist, Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, and Assistant Professor, Department of Pediatrics, University of Cincinnati, Ohio. Jean Tkach, PhD, is Associate Professor, Department of Radiology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Ohio. Andrew P. Salzwedel, PhD, is Project Scientist, Department of Biomedical Sciences, Cedars-Sinai Biomedical Imaging Research Institute-Gao Laboratory, Los Angeles, California. Weili Lin, PhD, is Professor of Radiology Neurology and Biomedical Engineering; Director of MR Research Center, Department of Radiology; Director, Small Animal Imaging Core Facility; Associate Director of Biomedical Research Imaging Center; and Vice Chair, Basic Research, Radiology, University of North Carolina, Chapel Hill. Wai Gao, PhD, is Associate Professor, Biomedical Sciences, and Director, Neuroimaging Research, Cedars-Sinai Medical Center, Los Angeles, California.
Stephanie Sealschott
Margo Moore
Stephanie Merhar
Jean Tkach
Andrew P Salzwedel
Weili Lin
Wai Gao
Imaging Center · USChildren's Hospital & Medical Center · USThe Ohio State University · USWeifang Medical University · CN

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Patterned Experience for Preterm InfantsR01NR012307 · NINR · OHIO STATE UNIVERSITY · PI PICKLER, RITA H · 2011 to 2015
$2.0M
NCATS NIH HHS UL1 TR001425NINR NIH HHS R01 NR012307
6 · The paper itself

Abstract

backgroundThe use of functional connectivity magnetic resonance imaging (fcMRI) in research involving preterm infants is relatively new, and its feasibility in this population is not fully established. However, fcMRI images reveal functional neural connections that may be useful in establishing the mechanisms of neuroprotective interventions in preterm infants.

objectiveThe aim of this study was to determine the feasibility of using fcMRI to measure differences in functional neural connections in nursing intervention studies.

methodsA pilot study was conducted as part of a longitudinal, randomized controlled trial (RCT) testing the effect of a feeding intervention on neurodevelopmental and clinical outcomes of preterm infants randomly assigned to one of two groups: a patterned feeding experience (PFE) group and a usual feeding care (UFC) group. The fcMRIs were done at term-equivalent age. Visual, motor, and default mode networks were analyzed.

resultsSeven infants were studied (four were in the PFE group, and three were in the UFC group). Participants were selected sequentially from the parent RCT. Clear images were obtained from all participants. Differences were noted among PFE and UFC infants: Infants receiving PFE were hyperconnective in the default mode (caudate, anterior cingulate cortex, and precuneus) and motor networks (middle temporal and middle occipital areas) and hypoconnective in others areas of the default mode (hippocampal and lingual regions) and motor networks (precentral and superior frontal cortices) relative to UFC infants. No differences were noted in visual networks. DISCUSSION: The feasibility of using fcMRI at term-equivalent age in preterm infants who participated in an RCT on the effect of a nursing intervention was shown. Differences in connectivity among infants by group were detected. Further research is needed to show the benefit of fcMRI in studies of preterm infants given the costs of the procedure as well as the uncertain relationship of this early outcome measure to long-term neurodevelopment.

Indexed as

Cerebral CortexFeasibility StudiesFeeding BehaviorFemaleFunctional NeuroimagingHumansInfant BehaviorInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleNeural PathwaysPilot ProjectsSucking Behavior

Identifiers

PMID29095379
PMCPMC5776701
OpenAlexW2765598788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.