ArticleMedicine2017
Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Suicide risk in patients undergoing hemodialysis: a systematic review and meta-analysis of prevalence.Renal failure · 2025Pooled it
- Work of being an adult patient with chronic kidney disease: a systematic review of qualitative studies.BMJ open · 2018Pooled it
- Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle-Brain-Renal Axis.International journal of environmental research and public health · 2021Trial
- Anxiety and depression symptomatology in adolescents with kidney disorders during transition: "perception of illness" and the "patient paradox".Pediatric nephrology (Berlin, Germany) · 2026Article
- Mental health and kidney disease.Nature reviews. Nephrology · 2026Review
- Patient-reported mental health problems and clinical outcomes in adults with non-dialysis chronic kidney disease.Kidney research and clinical practice · 2026Article
- Shared decision making and decision aids in the management of kidney disease and renal replacement treatment options.Current opinion in nephrology and hypertension · 2026Review
- Plasma brain-derived neurotrophic factor before hemodialysis reduces the risk of depression in patients with chronic renal failure.Renal failure · 2025Article
- Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study.Suicide & life-threatening behavior · 2025Observational
- Early-stage chronic kidney disease as a risk factor for suicide: a nationwide observational cohort study.Journal of nephrology · 2025Observational
- Suicide among patients with chronic kidney disease in the United States: 1999-2020.Journal of nephrology · 2024Article
- Comparison of depression and suicide between dialysis and kidney transplant recipients in Korea: a nationwide population study.Clinical transplantation and research · 2024Article
- Chronic kidney disease duration and suicide risk among maintenance hemodialysis patients in China.Clinical kidney journal · 2024Article
- Review
- Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study.Kidney research and clinical practice · 2023Article
- Stressors and Information-Seeking by Dialysis and Transplant Patients During COVID-19, Reported on a Telephone Hotline: A Mixed-Methods Study.Kidney medicine · 2022Article
- National Estimates of Mental Health Needs Among Adults With Self-Reported CKD in the United States.Kidney international reports · 2022Article
- Psychosocial barriers and facilitators for adherence to a healthy lifestyle among patients with chronic kidney disease: a focus group study.BMC nephrology · 2022Article
- The Association between Suicidal Ideation and Albuminuria in Korean Adults.Iranian journal of public health · 2022Article
- Evaluation of cerebral dysfunction in patients with chronic kidney disease using neuropsychometric and neurophysiological tests.Renal failure · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.09-1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m (OR, 1.11; 95% CI, 1.03-1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.
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