Structure of the staphylococcal enterotoxin B vaccine candidate S19 showing eliminated superantigen activity.

Woo Hyeon Jeong, Dong Hyun Song, Gyeung Haeng Hur, Seong Tae Jeong

Open access · hybridAbstract read

In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 86% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Woo Hyeon JeongThe 5th R&D Institute, Agency for Defense Development, Yuseong PO Box 35, Yuseong-gu, Daejeon 34188, Republic of Korea.

Dong Hyun SongThe 5th R&D Institute, Agency for Defense Development, Yuseong PO Box 35, Yuseong-gu, Daejeon 34188, Republic of Korea.

Gyeung Haeng HurThe 5th R&D Institute, Agency for Defense Development, Yuseong PO Box 35, Yuseong-gu, Daejeon 34188, Republic of Korea.

Seong Tae JeongThe 5th R&D Institute, Agency for Defense Development, Yuseong PO Box 35, Yuseong-gu, Daejeon 34188, Republic of Korea.

Agency for Defense Development · KR

Funding

Agency for Defense Development 07-203-603-005

6 · The paper itself

Abstract

Four mutations (N23A, Y90A, R110A and F177A) were introduced into S19, a vaccine candidate for staphylococcal enterotoxin B (SEB), resulting in a lower binding affinity towards the T-cell receptor beta chain (TCB) and reducing its superantigen activity. The structure of S19 was solved and was superposed on the native or complex structure of SEB. In the superposition model, mutations that were introduced seemed to reduce the number of hydrogen bonds at the SEB-TCB interface. S19 also displayed an unexpected structural change around the flexible-loop region owing to the Y90A mutation. This local structural change provided evidence that the mutated form of S19 could have a lower affinity for major histocompatibility complex (MHC) class II than wild-type SEB.

Indexed as

MutationCrystallography, X-RayEnterotoxinsHistocompatibility Antigens Class IIHydrogen BondingReceptors, Antigen, T-Cell, alpha-betaStaphylococcal Vaccinesenterotoxin B, staphylococcalEnterotoxinsHistocompatibility Antigens Class IIReceptors, Antigen, T-Cell, alpha-betaStaphylococcal Vaccinesbacterial superantigensrecombinant proteinSEBstaphylococcal enterotoxin BT-cell receptor beta chainvaccines

Identifiers

PMID29095152

DOI10.1107/S2053230X17014844

PMCPMC5683028

OpenAlexW2765670384

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.