Evidence map›Paper›PMID 29095087›Full record

ArticleAdipocyte2018

Elucidating the role of adipose tissue secreted factors in malignant transformation.

Debrup Chakraborty, Vanessa Benham, Jamie J Bernard

Open access · goldAbstract read
In one paragraph

Article in Adipocyte, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Debrup Chakrabortya Department of Pharmacology and Toxicology , Michigan State University , East Lansing , MI , USA.
Vanessa Benhama Department of Pharmacology and Toxicology , Michigan State University , East Lansing , MI , USA.
Jamie J Bernarda Department of Pharmacology and Toxicology , Michigan State University , East Lansing , MI , USA.
Michigan State University · US

Funding

The Role of Fat in Tumor FormationR00CA177868 · NCI · MICHIGAN STATE UNIVERSITY · PI BERNARD, JAMIE J · 2015 to 2017
$699k
NCI NIH HHS R00 CA177868
6 · The paper itself

Abstract

Although there is a growing number of incidences of obesity and obesity-linked cancers, how excess adiposity actually causes cancer has not been fully explained. Our previous study showed that removal of visceral adipose tissue significantly reduced the number of ultraviolet radiation (UVR)-initiated, high-fat diet-promoted skin cancers. This commentary focuses on our recently published study (Chakraborty, et al., 2017) which demonstrated that fibroblast growth factor-2 (FGF2) released from visceral adipose tissue is a key factor in the malignant transformation of epithelial cells. Within this commentary we have provided additional interpretations and new data in support of the role of FGF2 in adiposity-associated tumorigenesis.

Indexed as

Adipose TissueAdiposityBreast NeoplasmsDiet, High-FatFibroblast Growth Factor 2HumansIntra-Abdominal FatObesitySignal TransductionSkin NeoplasmsUltraviolet RaysFibroblast Growth Factor 2adipositybreast cancercancerFGF2obesityskin cancervisceral fat

Identifiers

PMID29095087
PMCPMC5915015
OpenAlexW2761254334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.