Evidence map›Paper›PMID 29094808›Full record

ArticleMolecular nutrition & food research2018

Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska.

Nicholas T Au, Tove Ryman, Allan E Rettie, Scarlett E Hopkins, Bert B Boyer, Jynene Black, Jacques Philip, Joseph Yracheta, Alison E Fohner, Morayma Reyes and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Nicholas T AuDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Tove RymanDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Allan E RettieDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
Scarlett E HopkinsCenter for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, AK, USA.
Bert B BoyerCenter for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, AK, USA.
Jynene BlackCenter for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, AK, USA.
Jacques PhilipCenter for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, AK, USA.
Joseph YrachetaDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Alison E FohnerInstitute for Public Health Genetics, University of Washington, Seattle, WA, USA.
Morayma ReyesDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Melissa A AustinDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
University of Washington · USNative Health · USInstitute for Systems Biology · USUniversity of Alaska Fairbanks · USUniversity of Washington Applied Physics Laboratory · US

Funding

Pharmacogenetics in Rural and Underserved PopulationsU01GM092676 · NIGMS · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G., THUMMEL, KENNETH E. · 2010 to 2014
$9.9M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Vitamin K gene network: Variant discovery and characterizationP01GM116691 · NIGMS · UNIVERSITY OF WASHINGTON · PI RETTIE, ALLAN EDWARD · 2016 to 2020
$7.6M
Pilot Project ProgramP30GM103325 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BOYER, BERT BRANDON · 2012 to 2016
$5.3M
Genetics of Obesity in Yup'ik EskimosR01DK074842 · NIDDK · UNIVERSITY OF ALASKA FAIRBANKS · PI BOYER, BERT BRANDON · 2007 to 2011
$2.8M
Institute for Translational Health Science (TL1)TL1RR025016 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$2.7M
New Vistas in Vitamin K MetabolismR01GM109743 · NIGMS · UNIVERSITY OF WASHINGTON · PI RETTIE, ALLAN EDWARD · 2013 to 2016
$1.1M
NCATS NIH HHS TL1 TR002318NCRR NIH HHS TL1 RR025016NIDDK NIH HHS R01 DK074842NIGMS NIH HHS P01 GM116691NIGMS NIH HHS P30 GM103325NIGMS NIH HHS R01 GM109743NIGMS NIH HHS U01 GM092676
6 · The paper itself

Abstract

scopeThe relationship between dietary vitamin K and plasma PIVKA-II concentration, a biomarker of hepatic vitamin K status, in a Yup'ik study population in southwestern Alaska is investigated. METHODS AND

resultsA total of 659 male and female, self-reported Yup'ik people, ≥14 years of age, were enrolled. Blood is collected for genotyping and plasma PIVKA-II biomarker analysis. A Yup'ik-specific dietary food frequency questionnaire is used to assess vitamin K intake. Among the participants, 22% report not consuming foods rich in vitamin K during the past year and 36% have a PIVKA-II concentration ≥ 2 ng mL

conclusionsA substantial proportion of the Yup'ik population exhibits vitamin K insufficiency, which is associated with low consumption of vitamin K rich foods and which might affect an individual's response to anticoagulant drugs such as warfarin that target the vitamin K cycle.

Indexed as

AdolescentAdultAgedAged, 80 and overAlaskaAlaska NativesCytochrome P450 Family 4DietFemaleHumansLiverMaleMiddle AgedNutritional StatusProthrombinVegetablesCYP4F2 protein, humanCytochrome P450 Family 4menatetrenoneProthrombinVitamin KVitamin K 1Vitamin K 2Alaska nativecoagulationCYP4F2PIVKA-IIvitamin K

Identifiers

PMID29094808
PMCPMC5803412
OpenAlexW2766943239

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.