ArticleHuman brain mapping2018
Functional dysconnectivity of the limbic loop of frontostriatal circuits in first-episode, treatment-naive schizophrenia.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRIJournal of psychiatry & neuroscience : JPN · 2020Pooled it
- Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions.Schizophrenia bulletin · 2024Article
- Increasing striatal dopamine release through repeated bouts of theta burst transcranial magnetic stimulation of the left dorsolateral prefrontal cortex. A 18F-desmethoxyfallypride positron emission tomography study.Frontiers in neuroscience · 2023Article
- The Relationship Between Frontostriatal Connectivity and Striatal Dopamine Function in Schizophrenia: An 18F-DOPA PET and Diffusion Tensor Imaging Study in Treatment Responsive and Resistant Patients.Psychiatry investigation · 2022Article
- Enhanced Resting-State Functional Connectivity of the Nucleus Accumbens in First-Episode, Medication-Naïve Patients With Early Onset Schizophrenia.Frontiers in neuroscience · 2022Article
- Abnormal functional connectivity of the frontostriatal circuits in type 2 diabetes mellitus.Frontiers in aging neuroscience · 2022Article
- Increased Excursions to Functional Networks in Schizophrenia in the Absence of Task.Frontiers in neuroscience · 2022Article
- The alternations of nucleus accumbent in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.Frontiers in psychiatry · 2022Article
- Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas.Frontiers in neurology · 2021Article
- Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.Journal of psychiatry & neuroscience : JPN · 2020Article
- Hormone levels are related to functional compensation in prolactinomas: A resting-state fMRI study.Journal of the neurological sciences · 2020Article
- Evidence for Decreased Density of Calretinin-Immunopositive Neurons in the Caudate Nucleus in Patients With Schizophrenia.Frontiers in neuroanatomy · 2020Article
- Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia.Frontiers in pharmacology · 2020Review
- Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population.Biological psychiatry · 2019Article
- Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia.Frontiers in psychiatry · 2019Article
- Functional dysconnectivity of the limbic loop of frontostriatal circuits in first-episode, treatment-naive schizophrenia.Human brain mapping · 2018Article
Corrections and comments
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ-related functional connectivity (FC) alterations in discrete frontostriatal circuits and their relationship with pathopsychology in first-episode schizophrenia (FESZ). The goal of this study was to identify dysfunctions in discrete frontostriatal circuits that are associated with key features of FESZ. To this end, a case-control, cross-sectional study was conducted, wherein resting-state (RS) functional magnetic resonance (fMRI) data were collected from 37 treatment-naïve FESZ patients and 29 healthy control (HC) subjects. Seed-based FC analyses were performed by placing six bilateral pairs of seeds within a priori defined subdivisions of the striatum. We observed significantly decreased FC for the FESZ group relative to the HC group [p < .05, family-wise error (FWE)-corrected] in the limbic loop, but not in the sensorimotor or associative loops, of frontostriatal circuitry. Moreover, bilaterally decreased inferior ventral striatum/nucleus accumbens (VSi)-dorsal anterior cingulate cortex (dACC) FC within the limbic loop correlated inversely with overall FESZ symptom severity and the disorganization factor score of PANSS. These findings provide new insight into the role of frontostriatal limbic loop hypoconnectivity in early-stage schizophrenia pathology and suggest potential novel therapeutic targets.
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