Evidence map›Paper›PMID 29094675›Full record

ArticlePsychological medicine2018

Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains.

R Blakey, S Ranlund, E Zartaloudi, W Cahn, S Calafato, M Colizzi, B Crespo-Facorro, C Daniel, Á Díez-Revuelta, M Di Forti and 24 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

R BlakeyDivision of Psychiatry,University College London,London,UK.
S RanlundDivision of Psychiatry,University College London,London,UK.
E ZartaloudiDivision of Psychiatry,University College London,London,UK.
W CahnDepartment of Psychiatry,Brain Centre Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
S CalafatoDivision of Psychiatry,University College London,London,UK.
M ColizziInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
B Crespo-FacorroCIBERSAM,Centro Investigación Biomédica en Red Salud Mental,Madrid,Spain.
C DanielDivision of Psychiatry,University College London,London,UK.
Á Díez-RevueltaDivision of Psychiatry,University College London,London,UK.
M Di FortiInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
GROUP
C IyegbeInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
A JablenskyCentre for Clinical Research in Neuropsychiatry,The University of Western Australia,Perth,Western Australia,Australia.
R JonesDivision of Psychiatry,University College London,London,UK.
M-H HallPsychology Research Laboratory,Harvard Medical School,McLean Hospital,Belmont, MA,USA.
R KahnDepartment of Psychiatry,Brain Centre Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
L KalaydjievaHarry Perkins Institute of Medical Research and Centre for Medical Research,The University of Western Australia,Perth,Australia.
E KravaritiInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
K LinInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
C McDonaldDepartment of Psychiatry,Clinical Science Institute,National University of Ireland Galway,Ireland.
A M McIntoshDivision of Psychiatry,University of Edinburgh,Royal Edinburgh Hospital,Edinburgh,UK.
M PicchioniInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
J PowellInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
A PresmanDivision of Psychiatry,University College London,London,UK.
D RujescuDepartment of Psychiatry,Ludwig-Maximilians University of Munich,Munich,Germany.
K SchulzeInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
M ShaikhNorth East London Foundation Trust,London,UK.
J H ThygesenDivision of Psychiatry,University College London,London,UK.
T ToulopoulouInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
N Van HarenDepartment of Psychiatry,Brain Centre Rudolf Magnus,University Medical Center Utrecht,Utrecht,The Netherlands.
J Van OsDepartment of Psychiatry and Psychology,Maastricht University Medical Centre,EURON,Maastricht,The Netherlands.
M WalsheDivision of Psychiatry,University College London,London,UK.
R M MurrayInstitute of Psychiatry Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust,London,UK.
E BramonDivision of Psychiatry,University College London,London,UK.

Funding

Neurobiological Markers as Predictors of Later Functional Outcome in First Episode PsychosisR01MH109687 · NIMH · MCLEAN HOSPITAL · PI HALL, MEI-HUA · 2016 to 2021
$2.5M
Department of Health PDA/02/06/016Medical Research Council G0901310Medical Research Council MR/K026992/1Medical Research Council MR/M008436/1NIMH NIH HHS R01 MH109687Wellcome Trust
6 · The paper itself

Abstract

backgroundA range of endophenotypes characterise psychosis, however there has been limited work understanding if and how they are inter-related.

methodsThis multi-centre study includes 8754 participants: 2212 people with a psychotic disorder, 1487 unaffected relatives of probands, and 5055 healthy controls. We investigated cognition [digit span (N = 3127), block design (N = 5491), and the Rey Auditory Verbal Learning Test (N = 3543)], electrophysiology [P300 amplitude and latency (N = 1102)], and neuroanatomy [lateral ventricular volume (N = 1721)]. We used linear regression to assess the interrelationships between endophenotypes.

resultsThe P300 amplitude and latency were not associated (regression coef. -0.06, 95% CI -0.12 to 0.01, p = 0.060), and P300 amplitude was positively associated with block design (coef. 0.19, 95% CI 0.10-0.28, p 0.38). All the cognitive endophenotypes were associated with each other in the expected directions (all p < 0.001). Lastly, the relationships between pairs of endophenotypes were consistent in all three participant groups, differing for some of the cognitive pairings only in the strengths of the relationships.

conclusionsThe P300 amplitude and latency are independent endophenotypes; the former indexing spatial visualisation and working memory, and the latter is hypothesised to index basic processing speed. Individuals with psychotic illnesses, their unaffected relatives, and healthy controls all show similar patterns of associations between endophenotypes, endorsing the theory of a continuum of psychosis liability across the population.

Indexed as

EndophenotypesAdolescentAdultAgedAged, 80 and overBrainCase-Control StudiesElectrophysiologyEvent-Related Potentials, P300FemaleHumansLinear ModelsMagnetic Resonance ImagingMaleMiddle AgedNerve NetLateral ventricular volumeP300schizophreniaunaffected relativesverbal memoryworking memory

Identifiers

PMID29094675
PMCPMC6516747

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.