Evidence map›Paper›PMID 29094518›Full record

Trial reportImmunity, inflammation and disease2018

Disparities in rate, triggers, and management in pediatric and adult cases of suspected drug-induced anaphylaxis in Canada.

Sofianne Gabrielli, Ann E Clarke, Harley Eisman, Judy Morris, Lawrence Joseph, Sebastien La Vieille, Peter Small, Rodrick Lim, Paul Enarson, Michal Zelcer and 3 more

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Immunity, inflammation and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 37 citations in OpenAlex.

  1. Triggers, clinical spectra and outcomes of pediatric anaphylaxis in a tertiary center: impact of comorbidities and cofactors on severity.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Drug Allergy in Children: What Should We Know?Clinical and experimental pediatrics · 2020
    Article
  8. Review
  9. Article
  10. Pediatric Drug Hypersensitivity.Current allergy and asthma reports · 2019
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Sofianne GabrielliDivision of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0002-1593-1081
Ann E ClarkeDivision of Rheumatology, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Harley EismanDepartment of Emergency Medicine, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Judy MorrisDepartment of Emergency Medicine, Hôpital du Sacré-Coeur, Montreal, Quebec, Canada.
Lawrence JosephDepartment of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada.
Sebastien La VieilleFood Directorate, Health Canada, Ottawa, Ontario, Canada.
Peter SmallDivision of Allergy and Clinical Immunology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Rodrick LimDepartment of Paediatrics and Emergency Medicine, Children's Hospital at London Health Science Centre, London, Ontario, Canada.
Paul EnarsonDivision of Emergency Medicine, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Michal ZelcerDivision of Emergency Medicine, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Edmond S ChanDivision of Allergy and Immunology, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Chris MillDivision of Allergy and Immunology, Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Moshe Ben-ShoshanDivision of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Quebec, Canada.
University of British Columbia · CAMcGill University Health Centre · CAHealth Canada · CAHôpital du Sacré-Cœur de Montréal · CAJewish General Hospital · CALondon Health Sciences Centre · CAMcGill University · CAMontreal Children's Hospital · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData is sparse on drug-induced anaphylaxis (DIA) and there have not been studies assessing the differences in clinical characteristics and management of DIA between adults and children.

objectiveWe assessed the percentage, diagnosis, and management of DIA among all anaphylaxis visits in three pediatric and one adult emergency departments (ED) across Canada.

methodsChildren presenting to the Montreal Children's Hospital (MCH), British Columbia Children's Hospital (BCCH), and Children's Hospital at London Health Sciences Center and adults presenting to Hôpital du Sacré-Coeur with anaphylaxis were recruited as part of the Cross-Canada Anaphylaxis Registry. A standardized data form documenting the reaction and management was completed and patients were followed annually to determine assessment by allergist and use of confirmatory tests.

resultsFrom June 2012 to May 2016, 51 children were recruited from the pediatric centers and 64 adults from the adult center with drug-induced anaphyalxis. More than half the cases were prospectively recruited. The percentage of DIA among all cases of anaphylaxis was similar in all three pediatric centers but higher in the adult center in Montreal. Most reactions in children were triggered by non-antibiotic drugs, and in adults, by antibiotics. The majority of adults and a third of children did not see an allergist after the initial reaction. In those that did see an allergist, diagnosis was established by either a skin test or an oral challenge in less than 20% of cases.

conclusionsOur results reveal disparities in rate, culprit, and management of DIA in children versus adults. Further, most cases of suspected drug allergy are not appropriately diagnosed. Guidelines to improve assessment and diagnosis of DIA are required.

Indexed as

Emergency Service, HospitalAdultAnaphylaxisCanadaChild, PreschoolDrug HypersensitivityFemaleHumansInfantMaleAnaphylaxisanti-bacterial agentsanti-inflammatory agents (non-steroidal)drug hypersensitivityskin tests

Identifiers

PMID29094518
PMCPMC5818453
OpenAlexW2766427826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.