ArticleWorld journal of orthopedics2017
Scaffolds based therapy for osteochondral lesions of the talus: A systematic review.
Article in World journal of orthopedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Enhanced microfracture using acellular scaffolds improves results after treatment of symptomatic focal grade III/IV knee cartilage lesions but current clinical evidence does not allow unequivocal recommendation.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Pooled it
- Prospective comparison of two different surgical technique in the treatment of deep osteochondral lesions of the talus: mosaicplasty versus all-arthroscopic technique with scaffold and autograft bone taken from the tibial plafond.Archives of orthopaedic and trauma surgery · 2024Trial
- Scaffolds for Osteochondral Lesions of the Talus: Systematic Review and Meta-Analysis of the Last Ten Years Literature.Bioengineering (Basel, Switzerland) · 2024Review
- Regeneration of Osteochondral Lesion of the Talus with Retrograde Drilling Technique: An In Vitro Pilot Study.Journal of clinical medicine · 2024Article
- Mid-term results of autologous matrix-induced chondrogenesis surgery with or without scaffolds for arthroscopic treatment of deep talus osteochondral lesions: A comparative study.Joint diseases and related surgery · 2023Article
- Talar OsteoPeriostic grafting from the Iliac Crest (TOPIC) for lateral osteochondral lesions of the talus: operative technique.Operative Orthopadie und Traumatologie · 2023Article
- Analysis of factors affecting the prognosis of osteochondral lesions of the talus.International orthopaedics · 2023Article
- Collagen Scaffold Application in Arthroscopic Reconstruction of Osteochondral Lesions of the Talus With Autologous Cancellous Bone Grafts.Orthopaedic journal of sports medicine · 2023Article
- Arthroscopic one-step matrix-assisted bone marrow stimulation for the treatment of osteochondral defects of the talus.Operative Orthopadie und Traumatologie · 2022Review
- Osteochondral Lesions of the Talus: A Review on Talus Osteochondral Injuries, Including Osteochondritis Dissecans.Cartilage · 2021Review
- Osteochondral Lesions of the Tibial Plafond: A Systematic Review.Orthopaedic journal of sports medicine · 2021Review
- Large variation in management of talar osteochondral lesions among foot and ankle surgeons: results from an international survey.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Article
- Talar OsteoPeriostic grafting from the Iliac Crest (TOPIC) for large medial talar osteochondral defects : Operative technique.Operative Orthopadie und Traumatologie · 2021Article
- Concomitant ankle instability has a negative impact on the quality of life in patients with osteochondral lesions of the talus: data from the German Cartilage Registry (KnorpelRegister DGOU).Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- Arthroscopic microfracture vs. arthroscopic autologous matrix-induced chondrogenesis for the treatment of articular cartilage defects of the talus.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus (OLT).
methodsA systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence (LOE) and quality of evidence (QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated.
resultsTwenty-eight studies for a total of 897 ankles were included; 96% were either LOE III or IV. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation (MACT), nine bone marrow derived cell transplantation (BMDCT), four autologous matrix-induced chondrogeneis (AMIC), and four studies of other techniques. The categories of general demographics (93%) and patient-reported outcome data (85%) were well reported. Study design (73%), imaging data (73%), clinical variables (49%), and patient history (30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society (AOFAS) score at final follow-up was: 86.7 in MACT, 88.2 in BMDCT, and 82.3 in AMIC. Eight studies reported that a weighted mean of 68.3% of patients returned to a previous level of sport activity.
conclusionScaffold-based therapy for OLT may produce favorable clinical outcomes, but low LOE, poor QOE, and variability of the data have confounded the effectiveness of this treatment.
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Registered trials
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