Evidence map›Paper›PMID 29094005›Full record

ArticleWorld journal of orthopedics2017

Bone regeneration with osteogenic matrix cell sheet and tricalcium phosphate: An experimental study in sheep.

Tsutomu Kira, Manabu Akahane, Shohei Omokawa, Takamasa Shimizu, Kenji Kawate, Tadanobu Onishi, Yasuhito Tanaka

Open access · hybridAbstract read
In one paragraph

Article in World journal of orthopedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tsutomu KiraDepartment of Orthopedic Surgery, Nara Medical University, Nara 634-8522, Japan. gs212005@naramed-u.ac.jp.
Manabu AkahaneDepartment of Public Health, Health Management and Policy, Nara Medical University School of Medicine, Nara 634-8522, Japan.
Shohei OmokawaDepartment of Hand Surgery, Nara Medical University, Nara 634-8522, Japan.
Takamasa ShimizuDepartment of Orthopedic Surgery, Nara Medical University, Nara 634-8522, Japan.
Kenji KawateDepartment of Artificial Joint and Regenerative Medicine for Bone and Cartilage, Nara Medical University, Nara 634-8522, Japan.
Tadanobu OnishiDepartment of Orthopedic Surgery, Nara Medical University, Nara 634-8522, Japan.
Yasuhito TanakaDepartment of Orthopedic Surgery, Nara Medical University, Nara 634-8522, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the effects of a cell sheet created from sheep bone marrow and tricalcium phosphate (TCP) on osteogenesis.

methodsBone marrow cells were harvested from a sheep and cultured in a minimal essential medium (MEM) containing ascorbic acid phosphate (AscP) and dexamethasone (Dex). After 2 wk, the formed osteogenic matrix cell sheet was lifted from the culture dish using a scraper. Additionally, harvested bone marrow cells were cultured in MEM only as a negative control group, and in MEM with AscP, Dex, and β-glycerophosphate as a positive control group. For

resultsIn the

conclusionThis technique for preparing highly osteoinductive TCP may promote regeneration in large bone defects.

Indexed as

Bone marrowCell sheetMesenchymal stromal cellOsteogenesisSheep

Identifiers

PMID29094005
PMCPMC5656490
OpenAlexW2765396665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.