Evidence map›Paper›PMID 29093987›Full record

ArticleJournal of periodontal & implant science2017

Targeting the epitope spreader Pep19 by naïve human CD45RA

Hyun-Joo Kim, Gil Sun Cha, Ji-Young Joo, Juyoun Lee, Sung-Jo Kim, Jeongae Lee, So Youn Park, Jeomil Choi

Open access · hybridAbstract read
In one paragraph

Article in Journal of periodontal & implant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Cell-based therapies for rheumatoid arthritis: opportunities and challenges.Therapeutic advances in musculoskeletal disease · 2022
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hyun-Joo KimDepartment of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Pusan National University School of Dentistry, Yangsan, Korea.ORCID https://orcid.org/0000-0001-7553-6289
Gil Sun ChaDepartment of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Pusan National University School of Dentistry, Yangsan, Korea.ORCID https://orcid.org/0000-0001-5804-0337
Ji-Young JooDepartment of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Pusan National University School of Dentistry, Yangsan, Korea.ORCID https://orcid.org/0000-0002-4050-5797
Juyoun LeeDepartment of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Pusan National University School of Dentistry, Yangsan, Korea.ORCID https://orcid.org/0000-0002-0772-033X
Sung-Jo KimDepartment of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Pusan National University School of Dentistry, Yangsan, Korea.ORCID https://orcid.org/0000-0002-1229-729X
Jeongae LeeMolecular Recognition Research Center, Korea Institute of Science and Technology, Seoul, Korea.ORCID https://orcid.org/0000-0002-7412-8977
So Youn ParkDepartment of Pharmacology, Pusan National University School of Medicine, Yangsan, Korea.ORCID https://orcid.org/0000-0002-3108-2534
Jeomil ChoiDepartment of Periodontology, Dental Research Institute, Pusan National University Dental Hospital, Pusan National University School of Dentistry, Yangsan, Korea.ORCID https://orcid.org/0000-0002-7491-6711
Pusan National University Dental Hospital · KRPusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBeyond the limited scope of non-specific polyclonal regulatory T cell (Treg)-based immunotherapy, which depends largely on serendipity, the present study explored a target Treg subset appropriate for the delivery of a novel epitope spreader Pep19 antigen as part of a sophisticated form of immunotherapy with defined antigen specificity that induces immune tolerance.

methodsHuman polyclonal CD4

resultsEpitope-spreader Pep19 targeting by 45RA-Tregs led to an outstanding

conclusionsWe propose human naïve CD4

Indexed as

Adoptive transferAutoimmune diseasesHeat-shock proteinsImmune toleranceRegulatory T-lymphocytesRheumatoid arthritis

Identifiers

PMID29093987
PMCPMC5663667
OpenAlexW2765835987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.