ReviewFrontiers in immunology2017
The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels.
Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Proton-Mediated PIEZO2 Channelopathy: Linking Oxaliplatin Treatment to Impaired Proprioception and Cognitive Deficits.Cancers · 2024Article
- Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response.Nature communications · 2024Article
- Current Status and Challenges Associated with CNS-Targeted Gene Delivery across the BBB.Pharmaceutics · 2020Review
- Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer.eLife · 2020Article
- Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs.Bioelectronic medicine · 2020Article
- Neural activity regulates autoimmune diseases through the gateway reflex.Bioelectronic medicine · 2019Review
- Neuroimmunometabolic alterations and severity of depressive symptoms in people with HIV: An exploratory diffusion-weighted MRS study.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
4 authors.
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Abstract
The gateway reflex is a new phenomenon that explains how immune cells bypass the blood-brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each described by the stimulus that evokes the reflex. Gravity, electricity, pain, and stress have all been found to create gateways at specific regions of the CNS. The gateway reflex, the most recently discovered of the four, has also been shown to upset the homeostasis of organs in the periphery through its action on the CNS. These reflexes provide novel therapeutic targets for the control of local neuroinflammation and organ function. Each gateway reflex is activated by different neural activations and induces inflmammation at different regions in the CNS. Therefore, it is theoretically possible to manipulate each independently, providing a novel therapeutic strategy to control local neuroinflammation and peripheral organ homeostasis.
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