ArticleScientific reports2017
Analysis of the CRISPR-Cas system in bacteriophages active on epidemic strains of Vibrio cholerae in Bangladesh.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Genomic Insight intoPathogens (Basel, Switzerland) · 2025Article
- Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system.Nature chemical biology · 2024Article
- Conditional Vitamin D Receptor Deletion Induces Fungal and Archaeal Dysbiosis and Altered Metabolites.Metabolites · 2024Article
- Article
- The Role of Temperate Phages in Bacterial Pathogenicity.Microorganisms · 2023Review
- Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.Advances in experimental medicine and biology · 2023Article
- CRISPR-Cas systems are present predominantly on chromosome and its relationship with MEGs in Vibrio species.Archives of microbiology · 2021Article
- Digging into the lesser-known aspects of CRISPR biology.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- Whole-Genome Sequence Data Analysis ofBioMed research international · 2021Article
- Identification and Characterization of the CRISPR/Cas System inFrontiers in microbiology · 2021Article
- Article
- Viral Satellites Exploit Phage Proteins to Escape Degradation of the Bacterial Host Chromosome.Cell host & microbe · 2019Article
- CRISPR-Cas in mobile genetic elements: counter-defence and beyond.Nature reviews. Microbiology · 2019Article
- Genome-wide correlation analysis suggests different roles of CRISPR-Cas systems in the acquisition of antibiotic resistance genes in diverse species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Competition between mobile genetic elements drives optimization of a phage-encoded CRISPR-Cas system: insights from a natural arms race.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- CRISPR-Cas systems are present predominantly on mobile genetic elements in Vibrio species.BMC genomics · 2019Article
- Niche adaptation limits bacteriophage predation ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- CRISPR-Cas System in Antibiotic Resistance Plasmids inFrontiers in microbiology · 2019Article
- Revisiting the Global Epidemiology of Cholera in Conjuction With the Genomics ofFrontiers in public health · 2019Review
- CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers.Frontiers in microbiology · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated proteins) are microbial nuclease systems involved in defense against phages. Bacteria also resist phages by hosting phage-inducible chromosomal islands (PICI) which prevent phage reproduction. Vibrio cholerae which causes cholera epidemics, interacts with numerous phages in the environment and in cholera patients. Although CRISPR-Cas systems are usually carried by bacteria and archea, recently V. cholerae specific ICP1 phages were found to host a CRISPR-Cas system that inactivates PICI-like elements (PLE) in V. cholerae. We analyzed a collection of phages and V. cholerae isolated during seasonal cholera epidemics in Bangladesh, to study the distribution, and recent evolution of the phage-encoded CRISPR-Cas system. Five distinct but related phages carrying the CRISPR-Cas system, and possible CRISPR-Cas negative progenitor phages were identified. Furthermore, CRISPR arrays in the phages were found to have evolved by acquisition of new spacers targeting diverse regions of PLEs carried by the V. cholerae strains, enabling the phages to efficiently grow on PLE positive strains. Our results demonstrate a continuing arms-race involving genetic determinants of phage-resistance in V. cholerae, and the phage-encoded CRISPR-Cas system in the co-evolution of V. cholerae and its phages, presumably fostered by their enhanced interactions during seasonal epidemics of cholera.
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