ArticleScientific reports2017
Asymmetric BMP4 signalling improves the realism of kidney organoids.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Ureter development and associated congenital anomalies.Nature reviews. Nephrology · 2025Review
- Review
- Kidney organoids: steps towards better organization and function.Biochemical Society transactions · 2024Review
- Production of kidney organoids arranged around single ureteric bud trees, and containing endogenous blood vessels, solely from embryonic stem cells.Scientific reports · 2022Article
- Renal engineering: strategies to address the problem of the ureter.Current opinion in biomedical engineering · 2021Article
- Differentiation of a Contractile, Ureter-Like Tissue, from Embryonic Stem Cell-Derived Ureteric Bud andJournal of the American Society of Nephrology : JASN · 2020Article
- Regulation of bone morphogenetic protein 4 on epithelial tissue.Journal of cell communication and signaling · 2020Review
- Engineering pattern formation and morphogenesis.Biochemical Society transactions · 2020Review
- Disease Modeling To Understand the Pathomechanisms of Human Genetic Kidney Disorders.Clinical journal of the American Society of Nephrology : CJASN · 2020Review
- Regenerative medicine therapies: lessons from the kidney.Current opinion in physiology · 2020Review
- Physical Activity Protects the Pathological Alterations of Alzheimer's Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways.Frontiers in cellular neuroscience · 2020Article
- Kidney Organoids as Disease Models: Strengths, Weaknesses and Perspectives.Frontiers in physiology · 2020Review
- Combining Kidney Organoids and Genome Editing Technologies for a Better Understanding of Physiopathological Mechanisms of Renal Diseases: State of the Art.Frontiers in medicine · 2020Review
- Smooth muscle contractility causes the gut to grow anisotropically.Journal of the Royal Society, Interface · 2019Article
- Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.Cell stem cell · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We present a strategy for increasing the anatomical realism of organoids by applying asymmetric cues to mimic spatial information that is present in natural embryonic development, and demonstrate it using mouse kidney organoids. Existing methods for making kidney organoids in mice yield developing nephrons arranged around a symmetrical collecting duct tree that has no ureter. We use transplant experiments to demonstrate plasticity in the fate choice between collecting duct and ureter, and show that an environment rich in BMP4 promotes differentiation of early collecting ducts into uroplakin-positive, unbranched, ureter-like epithelial tubules. Further, we show that application of BMP4-releasing beads in one place in an organoid can break the symmetry of the system, causing a nearby collecting duct to develop into a uroplakin-positive, broad, unbranched, ureter-like 'trunk' from one end of which true collecting duct branches radiate and induce nephron development in an arrangement similar to natural kidneys. The idea of using local symmetry-breaking cues to improve the realism of organoids may have applications to organoid systems other than the kidney.
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Registered trials
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