Evidence map›Paper›PMID 29093541›Full record

ArticleScientific reports2017

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.

Ouyang Chen, Zhiyong Cao, He Li, Zhouheng Ye, Rongjia Zhang, Ning Zhang, Junlong Huang, Ting Zhang, Liping Wang, Ling Han and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  9. Review
  10. Review
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  12. Fibrauretine reduces ischemia/reperfusion injury via RISK/eNOS activation.Naunyn-Schmiedeberg's archives of pharmacology · 2020
    Article
  13. Advances in the Protective Mechanism of NO, HFrontiers in cardiovascular medicine · 2020
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ouyang ChenDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Zhiyong CaoDepartment of Cardiology, No.411 Hospital of PLA, Shanghai, 200081, People's Republic of China.
He LiDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Zhouheng YeDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Rongjia ZhangDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Ning ZhangDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Junlong HuangDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Ting ZhangDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Liping WangDepartment of Anesthesiology, Fuzhou General Hospital of PLA, Fuzhou, 350025, Fujian Province, People's Republic of China.
Ling HanCentral Laboratory, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China.
Wenwu LiuDepartment of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China. liuwenwu1980@hotmail.com.
Xuejun SunDepartment of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, People's Republic of China. sunxjk@hotmail.com.ORCID 0000-0003-2387-5531
Second Military Medical University · CNFuzhou General Hospital of Nanjing Military Command · CNPeople's Liberation Army 411 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH (67% H

Indexed as

AnimalsCardiotonic AgentsHydrogenMice, Inbred C57BLMyocardial Reperfusion InjuryPhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktAkt1 protein, mouseCardiotonic AgentsHydrogenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt

Identifiers

PMID29093541
PMCPMC5665927
OpenAlexW2765547734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.