ArticleScientific reports2017
Intraoperative Assessment of Parathyroid Viability using Laser Speckle Contrast Imaging.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- Research status and frontier trends of near-infrared autofluorescence for parathyroid identification and protection: a bibliometric analysis from 2006 to 2026.Gland surgery · 2026Article
- Parathyroid autotransplantation: a phase-based framework for surgical decision-making.Frontiers in endocrinology · 2026Review
- Endoscopic laser speckle imaging enables real-time prediction of parathyroid function in thyroidectomy.Lasers in medical science · 2025Article
- Parathyroid glands viability assessment and identification during surgery with multimodal diffuse reflectance spectroscopy and NIR autofluorescence probe.Scientific reports · 2025Article
- Handheld laser speckle contrast imaging probe: quantitative video rate assessment of tissue perfusion in animal and patient applications.Biophotonics discovery · 2025Article
- The research progress of label-free optical imaging technology in intraoperative real-time navigation of parathyroid glands.Lasers in medical science · 2025Review
- Dual-mode optical projection mapping system: integration of laser speckle contrast and subcutaneous vein imaging.Biomedical engineering letters · 2024Article
- Sestamibi-guided thoracoscopic excision of functional mediastinal parathyroid adenoma in a child: A case report and review of literature.Journal of minimal access surgery · 2024Article
- Improved spatial speckle contrast model for tissue blood flow imaging: effects of spatial correlation among neighboring camera pixels.Journal of biomedical optics · 2023Article
- Comparing laser speckle contrast imaging and indocyanine green angiography for assessment of parathyroid perfusion.Scientific reports · 2023Article
- Projection mapping system for laser speckle contrast image: feasibility study for clinical application.Journal of biomedical optics · 2023Article
- Using Laser Speckle Contrast Imaging to Quantify Perfusion Quality in Kidney and Pancreas Grafts on Vascular Reperfusion: A Proof-of-Principle Study.Transplantation direct · 2023Article
- Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications.Surgery · 2023Article
- Near-infrared fluorescent imaging techniques for the detection and preservation of parathyroid glands during endocrine surgery.Innovative surgical sciences · 2022Article
- Prevalence and Risk Factors for Hypoparathyroidism Following Total Thyroidectomy in Taif City.Cureus · 2022Article
- Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands-A Meta-Narrative Review.Life (Basel, Switzerland) · 2022Review
- A pilot feasibility study to assess vascularity and perfusion of parathyroid glands using a portable hand-held imager.Lasers in surgery and medicine · 2022Article
- Management of Primary Hyperparathyroidism.Indian journal of surgical oncology · 2022Review
- Laser speckle contrast imaging to assess microcirculation.Cardiology journal · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
Post-surgical hypoparathyroidism and hypocalcemia are known to occur after nearly 50% of all thyroid surgeries as a result of accidental disruption of blood supply to healthy parathyroid glands, which are responsible for regulating calcium. However, there are currently no clinical methods for accurately identifying compromised glands and the surgeon relies on visual assessment alone to determine if any gland(s) should be excised and auto-transplanted. Here, we present Laser Speckle Contrast Imaging (LSCI) for real-time assessment of parathyroid viability. Taking an experienced surgeon's visual assessment as the gold standard, LSCI can be used to distinguish between well vascularized (n = 32) and compromised (n = 27) parathyroid glands during thyroid surgery with an accuracy of 91.5%. Ability to detect vascular compromise with LSCI was validated in parathyroidectomies. Results showed that this technique is able to detect parathyroid gland devascularization before it is visually apparent to the surgeon. Measurements can be performed in real-time and without the need to turn off operating room lights. LSCI shows promise as a real-time, contrast-free, objective method for helping reduce hypoparathyroidism after thyroid surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.