ArticleNature communications2017
Nigritoxin is a bacterial toxin for crustaceans and insects.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- A family of lethal exotoxins defined by cell entry via the Attractin receptor.bioRxiv : the preprint server for biology · 2025Article
- Interaction of insecticidal proteins from Pseudomonas spp. and Bacillus thuringiensis for boll weevil management.PloS one · 2023Article
- Crystal structure of bacterial cytotoxic necrotizing factor CNFThe EMBO journal · 2021Article
- Genome Sequence of Vibrio nigripulchritudo Strain TUMSAT-TG-2018, Isolated from Diseased Pacific White Shrimp,Microbiology resource announcements · 2020Article
- Ancestral gene acquisition as the key to virulence potential in environmental Vibrio populations.The ISME journal · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Tetraconata (Pancrustacea) concept proposes that insects are more closely related to aquatic crustaceans than to terrestrial centipedes or millipedes. The question therefore arises whether insects have kept crustacean-specific genetic traits that could be targeted by specific toxins. Here we show that a toxin (nigritoxin), originally identified in a bacterial pathogen of shrimp, is lethal for organisms within the Tetraconata and non-toxic to other animals. X-ray crystallography reveals that nigritoxin possesses a new protein fold of the α/β type. The nigritoxin N-terminal domain is essential for cellular translocation and likely encodes specificity for Tetraconata. Once internalized by eukaryotic cells, nigritoxin induces apoptotic cell death through structural features that are localized in the C-terminal domain of the protein. We propose that nigritoxin will be an effective means to identify a Tetraconata evolutionarily conserved pathway and speculate that nigritoxin holds promise as an insecticidal protein.
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Registered trials
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