Evidence map›Paper›PMID 29093445›Full record

ArticleNature communications2017

Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system.

Yibin Zhu, Rudian Zhang, Bei Zhang, Tongyan Zhao, Penghua Wang, Guodong Liang, Gong Cheng

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
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  11. Suitable Mouse Model to Study Dynamics of West Nile Virus Infection inTropical medicine and infectious disease · 2024
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Yibin ZhuTsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Rudian ZhangTsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.ORCID http://orcid.org/0000-0003-2214-4892
Bei ZhangTsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
Tongyan ZhaoState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
Penghua WangDepartment of Microbiology and Immunology, School of Medicine, New York Medical College, Valhalla, NY, 10595, USA.
Guodong LiangState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Viral Disease Control and Prevention, Beijing, 102206, China.
Gong ChengTsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. gongcheng@mail.tsinghua.edu.cn.
Center for Life Sciences · CNInstitute of Microbiology · CNKing Center · USNational Institute for Viral Disease Control and Prevention · CNNew York Medical College · USShenzhen Center for Disease Control and Prevention · CN

Funding

A critical role of NLRP6 in West Nile virus pathogenesis in miceR21AI103807 · NIAID · YALE UNIVERSITY · PI WANG, PENGHUA · 2014 to 2015
$438k
NIAID NIH HHS R21 AI103807
6 · The paper itself

Abstract

Mosquitoes are hematophagous insects that carry-on and transmit many human viruses. However, little information is available regarding the common mechanisms underlying the infection of mosquitoes by these viruses. In this study, we reveal that the hematophagous nature of mosquitoes contributes to arboviral infection after a blood meal, which suppresses antiviral innate immunity by activating the GABAergic pathway. dsRNA-mediated interruption of the GABA signaling and blockage of the GABA

Indexed as

AedesAnimalsArbovirusesBloodBunyamwera virusCulexDengue VirusEncephalitis Virus, CaliforniaEncephalitis Virus, JapaneseGABA-A Receptor Antagonistsgamma-Aminobutyric AcidHumansImmunity, InnateMosquito VectorsReceptors, GABA-ARNA, Double-StrandedGABA-A Receptor Antagonistsgamma-Aminobutyric AcidReceptors, GABA-ARNA, Double-Stranded

Identifiers

PMID29093445
PMCPMC5665997
OpenAlexW2766824441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.