ArticleNature communications2017
Developmental increases in white matter network controllability support a growing diversity of brain dynamics.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed.
- Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Effect of methylphenidate on functional controllability: a preliminary study in medication-naïve children with ADHD.Translational psychiatry · 2022Trial
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- Structural and dynamic functional controllability: shared variance between network control metrics limits attribution to distinct domains of intelligence.Frontiers in human neuroscience · 2026Article
- Cerebral network topology and peak width of skeletonized mean diffusivity changes associated with cognitive impairment in patients with obstructive sleep apnea.Brain imaging and behavior · 2025Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
- Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy.Nature communications · 2025Article
- Mapping the coupling between tract reachability and cortical geometry of the human brain.Nature communications · 2025Article
- The Neural Association Between Symptom and Cognition in Major Depressive Disorder: A Network Control Theory Study.Human brain mapping · 2025Article
- The control costs of human brain dynamics.Network neuroscience (Cambridge, Mass.) · 2025Article
- Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates.Network neuroscience (Cambridge, Mass.) · 2025Article
- A network control theory pipeline for studying the dynamics of the structural connectome.Nature protocols · 2024Article
- Dynamic transient brain states in preschoolers mirror parental report of behavior and emotion regulation.Human brain mapping · 2024Article
- Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies.Nature biomedical engineering · 2024Article
- Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder.EBioMedicine · 2024Article
- Stimulus type shapes the topology of cellular functional networks in mouse visual cortex.Nature communications · 2024Article
- Effects of topology on the controllability of brain connectomes through sparsity promoting control.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Compensatory mechanisms amidst demyelinating disorders: insights into cognitive preservation.Brain communications · 2024Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
As the human brain develops, it increasingly supports coordinated control of neural activity. The mechanism by which white matter evolves to support this coordination is not well understood. Here we use a network representation of diffusion imaging data from 882 youth ages 8-22 to show that white matter connectivity becomes increasingly optimized for a diverse range of predicted dynamics in development. Notably, stable controllers in subcortical areas are negatively related to cognitive performance. Investigating structural mechanisms supporting these changes, we simulate network evolution with a set of growth rules. We find that all brain networks are structured in a manner highly optimized for network control, with distinct control mechanisms predicted in child vs. older youth. We demonstrate that our results cannot be explained by changes in network modularity. This work reveals a possible mechanism of human brain development that preferentially optimizes dynamic network control over static network architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.