Evidence map›Paper›PMID 29093276›Full record

ArticleJournal of atherosclerosis and thrombosis2018

Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function.

Ryo Shimomura, Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Takamichi Sugimoto, Naoto Kinoshita, Mutsuko Araki, Tetsuya Takahashi, Hirofumi Maruyama, Masayasu Matsumoto

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
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  9. Article
  10. Proteomics Analysis of Serum Proteins in Gestational Diabetes.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
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  13. Evaluation of Hypoglycemic Therapy Through Physical Exercise in n5STZ-Induced Diabetes Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ryo ShimomuraDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Tomohisa NezuDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Naohisa HosomiDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Shiro AokiDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Takamichi SugimotoDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Naoto KinoshitaDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Mutsuko ArakiDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Tetsuya TakahashiDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Hirofumi MaruyamaDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Masayasu MatsumotoDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences.
Hiroshima University · JPHoshigaoka Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAlpha-2-macroglobulin (

methodsPatients with a history of stroke or any established cardiovascular risk factors were enrolled in this study (n=102; 69 men, 70.1±9.2 years). Endothelial function was assessed by flow-mediated dilation (FMD). EPC numbers (CD34+/CD133+) were measured using flow cytometry (n=91). Serum

resultsPatients in the highest tertile of serum

conclusionSerum

Indexed as

AgedAtherosclerosisBiomarkersCardiovascular DiseasesDyslipidemiasEndothelial Progenitor CellsEndothelium, VascularFemaleFlow CytometryGlomerular Filtration RateHumansHypertensionInflammationMagnetic Resonance ImagingMaleMiddle AgedBiomarkersPregnancy-Associated alpha 2-MacroglobulinsBiological markerEndothelial dysfunctionEndothelial progenitor cellFlow-mediated dilationStroke

Identifiers

PMID29093276
PMCPMC5906188
OpenAlexW2766513643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.