ArticleProceedings. Biological sciences2017
Identification of a molecular pH sensor in coral.
Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Intracellular acid-base regulation mediates a trade-off between shell and somatic growth in a clam under ocean acidification.iScience · 2026Article
- Soluble adenylyl cyclase in nonmammalian sperm is directly controlled by pH, not by HCOProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The temperate coralRoyal Society open science · 2025Article
- Article
- Co-option of immune and digestive cellular machinery to support photosymbiosis in amoebocytes of the upside-down jellyfish Cassiopea xamachana.The Journal of experimental biology · 2025Article
- Characterization of a sperm motility signalling pathway in a gonochoric coral suggests conservation across cnidarian sexual systems.Proceedings. Biological sciences · 2023Article
- Synergistic and antagonistic interactions of oxybenzone and ocean acidification: new insight into vulnerable cellular processes in non-calcifying anthozoans.Frontiers in physiology · 2023Article
- Spiropyran-Merocyanine Based Photochromic Fluorescent Probes: Design, Synthesis, and Applications.ACS omega · 2022Review
- Environmental memory gained from exposure to extreme pCOProceedings. Biological sciences · 2022Article
- A Rhesus channel in the coral symbiosome membrane suggests a novel mechanism to regulate NHScience advances · 2022Article
- Molecular mechanisms of sperm motility are conserved in an early-branching metazoan.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular and biochemical characterization of the bicarbonate-sensing soluble adenylyl cyclase from a bony fish, the rainbow troutInterface focus · 2021Article
- Intracellular pH regulation: characterization and functional investigation of HBMC molecular and cell biology · 2021Article
- Immunological characterization of two types of ionocytes in the inner ear epithelium of Pacific Chub Mackerel (Scomber japonicus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- How corals made rocks through the ages.Global change biology · 2020Review
- A vesicular Na+/Ca2+ exchanger in coral calcifying cells.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintaining stable intracellular pH (pHi) is essential for homeostasis, and requires the ability to both sense pH changes that may result from internal and external sources, and to regulate downstream compensatory pH pathways. Here we identified the cAMP-producing enzyme soluble adenylyl cyclase (sAC) as the first molecular pH sensor in corals. sAC protein was detected throughout coral tissues, including those involved in symbiosis and calcification. Application of a sAC-specific inhibitor caused significant and reversible pHi acidosis in isolated coral cells under both dark and light conditions, indicating sAC is essential for sensing and regulating pHi perturbations caused by respiration and photosynthesis. Furthermore, pHi regulation during external acidification was also dependent on sAC activity. Thus, sAC is a sensor and regulator of pH disturbances from both metabolic and external origin in corals. Since sAC is present in all coral cell types, and the cAMP pathway can regulate virtually every aspect of cell physiology through post-translational modifications of proteins, sAC is likely to trigger multiple homeostatic mechanisms in response to pH disturbances. This is also the first evidence that sAC modulates pHi in any non-mammalian animal. Since corals are basal metazoans, our results indicate this function is evolutionarily conserved across animals.
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Registered trials
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