Evidence map›Paper›PMID 29093093›Full record

ArticleJournal of virology2018

Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections.

Xiaoli Xiong, M Alejandra Tortorici, Joost Snijder, Craig Yoshioka, Alexandra C Walls, Wentao Li, Andrew T McGuire, Félix A Rey, Berend-Jan Bosch, David Veesler

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 165 citations in OpenAlex.

  1. Article
  2. Article
  3. Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Serial cell culture passagingJournal of virology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Broadly neutralizing antibodies against emerging delta-coronaviruses.bioRxiv : the preprint server for biology · 2024
    Article
  17. Human coronavirus HKU1 recognition of the TMPRSS2 host receptor.bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. TheFrontiers in veterinary science · 2024
    Article
  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Xiaoli XiongDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
M Alejandra TortoriciInstitut Pasteur, Unité de Virologie Structurale, Paris, France.
Joost SnijderDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Craig YoshiokaDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA.
Alexandra C WallsDepartment of Biochemistry, University of Washington, Seattle, Washington, USA.
Wentao LiVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Andrew T McGuireVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Félix A ReyInstitut Pasteur, Unité de Virologie Structurale, Paris, France.
Berend-Jan BoschVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
David VeeslerDepartment of Biochemistry, University of Washington, Seattle, Washington, USA dveesler@uw.edu.
University of Washington · USInstitut Pasteur · FRUtrecht University · NLFred Hutch Cancer Center · USOregon Health & Science University · US

Funding

TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
Structural Studies of Coronavirus Fusion ProteinsR01GM120553 · NIGMS · UNIVERSITY OF WASHINGTON · PI VEESLER, DAVID · 2016 to 2020
$1.7M
NIAID NIH HHS HHSN272201700059CNIGMS NIH HHS R01 GM120553NIGMS NIH HHS T32 GM008268
6 · The paper itself

Abstract

Coronaviruses recently emerged as major human pathogens causing outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome. They utilize the spike (S) glycoprotein anchored in the viral envelope to mediate host attachment and fusion of the viral and cellular membranes to initiate infection. The S protein is a major determinant of the zoonotic potential of coronaviruses and is also the main target of the host humoral immune response. We report here the 3.5-Å-resolution cryo-electron microscopy structure of the S glycoprotein trimer from the pathogenic porcine deltacoronavirus (PDCoV), which belongs to the recently identified

Indexed as

Membrane FusionVirus AttachmentAnimalsCoronaviridaeCoronaviridae InfectionsDrosophila melanogasterHumansPolysaccharidesProtein ConformationSpike Glycoprotein, CoronavirusSwineSwine DiseasesPolysaccharidesSpike Glycoprotein, Coronaviruscoronavirusescryo-EMfusion proteins

Identifiers

PMID29093093
PMCPMC5790929
OpenAlexW2766504265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.