Evidence map›Paper›PMID 29093061›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

Ruan Zhang, Peter T Sage, Kelsey Finn, Alexandria Huynh, Bruce R Blazar, Francesco Marangoni, Thorsten R Mempel, Arlene H Sharpe, Laurence A Turka

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  6. Ex-TFRs: A Missing Piece of the SLE Puzzle?Frontiers in immunology · 2021
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ruan ZhangCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129.
Peter T SageDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Kelsey FinnCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129.
Alexandria HuynhCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129.
Bruce R BlazarDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455; and.ORCID 0000-0002-9608-9841
Francesco MarangoniCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129.ORCID 0000-0002-2490-849X
Thorsten R MempelCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129.ORCID 0000-0001-8635-5424
Arlene H SharpeDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
Laurence A TurkaCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA 02129; lturka@partners.org.
Massachusetts General Hospital · USBrigham and Women's Hospital · USUniversity of Minnesota · US

Funding

Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Bruce R Blazar · 1995 to 2026
$48.2M
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Project 3: Humoral Targets and B Cell Biology in Chronic Graft-vs.-Host DiseaseP01CA142106 · NCI · DANA-FARBER CANCER INST · PI CUTLER, COREY S · 2009 to 2019
$17.5M
P3: Chemokine-Mediated T Cell Trafficking in HIV Transmission and Immune ResponseP01AI112521 · NIAID · HARVARD MEDICAL SCHOOL · PI LUSTER, ANDREW · 2014 to 2018
$9.8M
Enhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7M
IN VIVO ROLE OF CTLA-4 IN COSTIMULATION AND AUTOIMMUNITYR01AI040614 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 1997 to 2018
$6.3M
T-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4M
In Vivo Prevention of Murine GVHDR37AI034495 · NIAID · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar · 2017 to 2026
$5.4M
TOLERANCE INDUCTION BY DST PLUS COSTIMULATORY BLOCKADER01AI037691 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TURKA, LAURENCE A · 1995 to 2015
$5.3M
NCI NIH HHS P01 CA065493NCI NIH HHS P01 CA142106NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NIAID NIH HHS P01 AI056299NIAID NIH HHS P01 AI112521NIAID NIH HHS R01 AI037691NIAID NIH HHS R01 AI040614NIAID NIH HHS R37 AI034495NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Follicular regulatory T (T

Indexed as

AnimalsAntibody FormationAutoimmune DiseasesAutoimmunityB-LymphocytesCD28 AntigensCD4-Positive T-LymphocytesCytokinesFemaleGerminal CenterImmune ToleranceLungLymphadenopathyLymphocyte DepletionLymphopoiesisMiceCD28 AntigensCytokines

Identifiers

PMID29093061
PMCPMC5716898
OpenAlexW2765757432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.