Evidence map›Paper›PMID 29092954›Full record

ArticleCancer research2017

DeepPhe: A Natural Language Processing System for Extracting Cancer Phenotypes from Clinical Records.

Guergana K Savova, Eugene Tseytlin, Sean Finan, Melissa Castine, Timothy Miller, Olga Medvedeva, David Harris, Harry Hochheiser, Chen Lin, Girish Chavan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Efficient extraction of medication information from clinical notes: an evaluation in 2 languages.Journal of the American Medical Informatics Association : JAMIA · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. An Implemented Real-World-Data Pipeline for Standardization of Electronic Health Records in Precision Oncology.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Guergana K SavovaBoston Children's Hospital, Boston, Massachusetts. Guergana.Savova@childrens.harvard.edu.
Eugene TseytlinDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Sean FinanBoston Children's Hospital, Boston, Massachusetts.
Melissa CastineDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Timothy MillerBoston Children's Hospital, Boston, Massachusetts.
Olga MedvedevaDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
David HarrisBoston Children's Hospital, Boston, Massachusetts.
Harry HochheiserDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Chen LinBoston Children's Hospital, Boston, Massachusetts.
Girish ChavanDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Rebecca S JacobsonDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania.
Harvard University · USUPMC Hillman Cancer Center · US

Funding

Temporal relation discovery for clinical textR01LM010090 · NLM · BOSTON CHILDREN'S HOSPITAL · PI MARTIN, JAMES H., SAVOVA, GUERGANA K. · 2010 to 2022
$7.1M
Cancer Deep Phenotype Extraction from Electronic Medical RecordsU24CA184407 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAVOVA, GUERGANA K. · 2014 to 2018
$4.4M
Informatics Tools for Pharmacogenomic Discovery using Practice-based DataR01GM103859 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., PATHAK, JYOTISHMAN · 2014 to 2017
$2.4M
NCI NIH HHS U24 CA184407NIGMS NIH HHS R01 GM103859NLM NIH HHS R01 LM010090
6 · The paper itself

Abstract

Precise phenotype information is needed to understand the effects of genetic and epigenetic changes on tumor behavior and responsiveness. Extraction and representation of cancer phenotypes is currently mostly performed manually, making it difficult to correlate phenotypic data to genomic data. In addition, genomic data are being produced at an increasingly faster pace, exacerbating the problem. The DeepPhe software enables automated extraction of detailed phenotype information from electronic medical records of cancer patients. The system implements advanced Natural Language Processing and knowledge engineering methods within a flexible modular architecture, and was evaluated using a manually annotated dataset of the University of Pittsburgh Medical Center breast cancer patients. The resulting platform provides critical and missing computational methods for computational phenotyping. Working in tandem with advanced analysis of high-throughput sequencing, these approaches will further accelerate the transition to precision cancer treatment.

Indexed as

Computer SystemsElectronic Health RecordsNatural Language ProcessingData MiningHumansMedical InformaticsNeoplasmsPhenotypePrecision MedicineReproducibility of Results

Identifiers

PMID29092954
PMCPMC5690492
OpenAlexW2765488845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.